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• W2152660247 abstract "In addition to balancing X-chromosome dosage between males and females via X inactivation, mammals also balance dosage of X chromosomes and autosomes. Allele-specific chromatin immunoprecipitation with deep sequencing (ChIP-seq) analyses now show that the active X chromosome is upregulated at the level of both transcription initiation and elongation. Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate mechanism, we perform allele-specific ChIP-seq for chromatin epitopes and analyze RNA-seq data. The hypertranscribed Xa demonstrates enrichment of active chromatin marks relative to autosomes. We derive predictive models for relationships among Pol II occupancy, active mark densities and gene expression, and we suggest that Xa upregulation involves increased transcription initiation and elongation. Enrichment of active marks on Xa does not scale proportionally with transcription output, a disparity explained by nonlinear quantitative dependencies among active histone marks, Pol II occupancy and transcription. Notably, the trend of nonlinear upregulation also occurs on autosomes. Thus, Xa upregulation involves combined increases of active histone marks and Pol II occupancy, without invoking X-specific dependencies between chromatin states and transcription." @default.
• W2152660247 created "2016-06-24" @default.
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• W2152660247 date "2011-12-04" @default.
• W2152660247 modified "2023-09-30" @default.
• W2152660247 title "X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription" @default.
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• W2152660247 doi "https://doi.org/10.1038/nsmb.2195" @default.
• W2152660247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732781" @default.
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• W2152660247 hasPublicationYear "2011" @default.
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