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- W2152665105 abstract "Abstract Context.—Retinoblastoma is the most common malignant intraocular tumor in children. It has been shown that adjuvant therapy following enucleation in patients with high-risk histopathologic features significantly decreases the mortality. We describe the association of extensive necrosis of tumor and intraocular structures with 2 of the major risk factors: optic nerve invasion and choroidal invasion. This may alert the pathologist who makes the observation of extensive necrosis to carefully search for histologic features associated with adverse outcome. Objective.—To determine whether extensively necrotic retinoblastoma is associated with high-risk histologic prognostic factors for metastatic disease and patient survival. Design.—Retrospective case series. Forty-three eyes of 43 patients with retinoblastoma who underwent enucleation between 1990 and 2001 were evaluated. Medical records, histopathology specimens, pathology reports, and clinical photographs were reviewed. Tumors were designated as ex..." @default.
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- W2152665105 date "2006-11-01" @default.
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- W2152665105 title "Extensively Necrotic Retinoblastoma Is Associated With High-Risk Prognostic Factors" @default.
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- W2152665105 doi "https://doi.org/10.1043/1543-2165(2006)130[1669:enriaw]2.0.co;2" @default.
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