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• W2152665902 abstract "Astrocytes play a vital role in neuronal protection, homeostasis, vascular interchange and the local immune response. Some viruses and parasites can cross the blood-brain barrier and infect glia. Trypanosoma cruzi, the aetiological agent of Chagas disease, can seriously compromise the central nervous system, mainly in immune-suppressed individuals, but also during the acute phase of the infection. In this report, the infective capacity of T. cruzi in a human astrocyte tumour-derived cell line was studied. Astrocytes exposed to trypomastigotes (1:10 ratio) produced intracellular amastigotes and new trypomastigotes emerged by day 4 post-infection (p.i.). At day 6 p.i., 93% of the cells were infected. Using flow cytometry, changes were observed in both the expression of major histocompatibility complex class I and II molecules and the chemokine secretion pattern of astrocytes exposed to the parasite. Blocking the low-density lipoprotein receptor on astrocytes did not reduce parasite intracellular infection. Thus, T. cruzi can infect astrocytes and modulate the immune response during central nervous system infection." @default.
• W2152665902 created "2016-06-24" @default.
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• W2152665902 date "2013-04-01" @default.
• W2152665902 modified "2023-10-02" @default.
• W2152665902 title "A human astrocytoma cell line is highly susceptible to infection with Trypanosoma cruzi" @default.
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• W2152665902 doi "https://doi.org/10.1590/0074-0276108022013014" @default.
• W2152665902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3970672" @default.
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