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- W2152695725 abstract "Abstract The RNA world hypothesis describes a stage in the early evolution of life in which RNA served as genome and as the only genome-encoded catalyst. To test whether RNA world organisms could have used cyclic trimetaphosphate as an energy source, we developed an in vitro selection strategy for isolating ribozymes that catalyze the triphosphorylation of RNA 5′-hydroxyl groups with trimetaphosphate. Several active sequences were isolated, and one ribozyme was analyzed in more detail. The ribozyme was truncated to 96 nt, while retaining full activity. It was converted to a trans-format and reacted with rates of 0.16 min−1 under optimal conditions. The secondary structure appears to contain a four-helical junction motif. This study showed that ribozymes can use trimetaphosphate to triphosphorylate RNA 5′-hydroxyl groups and suggested that RNA world organisms could have used trimetaphosphate as their energy source." @default.
- W2152695725 created "2016-06-24" @default.
- W2152695725 creator A5015338246 @default.
- W2152695725 creator A5070230243 @default.
- W2152695725 date "2014-01-21" @default.
- W2152695725 modified "2023-10-17" @default.
- W2152695725 title "A ribozyme that triphosphorylates RNA 5′-hydroxyl groups" @default.
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- W2152695725 doi "https://doi.org/10.1093/nar/gkt1405" @default.
- W2152695725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985629" @default.
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- W2152695725 hasPublicationYear "2014" @default.
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