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• W2152695876 abstract "Polyhalogenated organic pollutants are xenobiotics, which are believed to cause considerable environmental pollution and human health problems as a result of their persistence, toxicity, and transformation into hazardous metabolites. These chemicals are persistent and are biomagnificated in the ecosystem. Amphibians (frogs) are considered as reliable indicators of environmental health because they form an important link in the food chain between insects and vertebrates. Furthermore, they are inhabitants of bothaquatic and terrestrial environments and occupy different positions in the food web at different stages of their life cycle. The different stages in the life cycle of frogs are tadpole, juvenile and adult stages.The tadpole is transformed to a juvenile frog by metamorphosis. Disruption of this life cycle by xenobiotics can have disastrous effects on the amphibian populations. Polyhalogenated organic compounds have been known to cause endocrine disruption, effects on gene expression and induction of cytochrome P 450 enzymes in frogs. The present study was conducted to compare the tissue disposition of a polybrominated compound, 2, 2', 4, 4', 5-pentabromodiphenyl ether (BDE 99) in tadpole and juvenile stages of Xenopus tropicalis (West African clawed frog). The study was performed using whole-body autoradiography and scintillation counting at different time intervals after dietary exposures of 14CBDE 99 at stage 54 (tadpoles) and stage 66 (juvenile frogs). From the results of the study it was concluded that there was a significantdifference between the uptake and retention of the chemical between tadpoles and frogs. Juvenile frogs had higher uptake and retention of the radio labelled chemical than tadpoles. The substance was retained in adipose tissue over 64 days in both stages. However, the localisation of substance was similar in both stages." @default.
• W2152695876 created "2016-06-24" @default.
• W2152695876 creator A5061123851 @default.
• W2152695876 date "2011-11-18" @default.
• W2152695876 modified "2023-09-27" @default.
• W2152695876 title "Polyhalogenated Organic Pollutants in Amphibians" @default.
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