FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152804723> ?p ?o ?g. }

• W2152804723 endingPage "G902" @default.
• W2152804723 startingPage "G895" @default.
• W2152804723 abstract "Dietary protein is a major stimulant for cholecystokinin (CCK) secretion by the intestinal I cell, however, the mechanism by which protein is detected is unknown. Indirect functional evidence suggests that PepT1 may play a role in CCK-mediated changes in gastric motor function. However, it is unclear whether this oligopeptide transporter directly or indirectly activates the I cell. Using both the CCK-expressing enteroendocrine STC-1 cell and acutely isolated native I cells from CCK-enhanced green fluorescent protein (eGFP) mice, we aimed to determine whether PepT1 directly activates the enteroendocrine cell to elicit CCK secretion in response to oligopeptides. Both STC-1 cells and isolated CCK-eGFP cells expressed PepT1 transcripts. STC-1 cells were activated, as measured by ERK(1/2) phosphorylation, by both peptone and the PepT1 substrate Cefaclor; however, the PepT1 inhibitor 4-aminomethyl benzoic acid (AMBA) had no effect on STC-1 cell activity. The PepT1-transportable substrate glycyl-sarcosine dose-dependently decreased gastric motility in anesthetized rats but had no affect on activation of STC-1 cells or on CCK secretion by CCK-eGFP cells. CCK secretion was significantly increased in response to peptone but not to Cefaclor, cephalexin, or Phe-Ala in CCK-eGFP cells. Taken together, the data suggest that PepT1 does not directly mediate CCK secretion in response to PepT1 specific substrates. PepT1, instead, may have an indirect role in protein sensing in the intestine." @default.
• W2152804723 created "2016-06-24" @default.
• W2152804723 creator A5020411590 @default.
• W2152804723 creator A5035114986 @default.
• W2152804723 creator A5042185667 @default.
• W2152804723 creator A5062246921 @default.
• W2152804723 creator A5065348218 @default.
• W2152804723 creator A5080649327 @default.
• W2152804723 date "2011-05-01" @default.
• W2152804723 modified "2023-10-15" @default.
• W2152804723 title "Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1" @default.
• W2152804723 cites W1509487637 @default.
• W2152804723 cites W1600349900 @default.
• W2152804723 cites W1608042950 @default.
• W2152804723 cites W1924718359 @default.
• W2152804723 cites W1928410833 @default.
• W2152804723 cites W1964781869 @default.
• W2152804723 cites W1969141131 @default.
• W2152804723 cites W1969699155 @default.
• W2152804723 cites W1985592310 @default.
• W2152804723 cites W1986893992 @default.
• W2152804723 cites W1987307039 @default.
• W2152804723 cites W1992364351 @default.
• W2152804723 cites W2014379721 @default.
• W2152804723 cites W2020739410 @default.
• W2152804723 cites W2026151238 @default.
• W2152804723 cites W2038915304 @default.
• W2152804723 cites W2041609743 @default.
• W2152804723 cites W2041624484 @default.
• W2152804723 cites W2043420595 @default.
• W2152804723 cites W2044174926 @default.
• W2152804723 cites W2045343006 @default.
• W2152804723 cites W2048594260 @default.
• W2152804723 cites W2059117845 @default.
• W2152804723 cites W2061838703 @default.
• W2152804723 cites W2071080566 @default.
• W2152804723 cites W2072474474 @default.
• W2152804723 cites W2072901635 @default.
• W2152804723 cites W2076511407 @default.
• W2152804723 cites W2091591105 @default.
• W2152804723 cites W2093539095 @default.
• W2152804723 cites W2106652431 @default.
• W2152804723 cites W2116417009 @default.
• W2152804723 cites W2117597932 @default.
• W2152804723 cites W2132613598 @default.
• W2152804723 cites W2132734800 @default.
• W2152804723 cites W2140141031 @default.
• W2152804723 cites W2148049649 @default.
• W2152804723 cites W2149138443 @default.
• W2152804723 cites W2163903330 @default.
• W2152804723 cites W2172047282 @default.
• W2152804723 cites W2416764398 @default.
• W2152804723 cites W2416843929 @default.
• W2152804723 doi "https://doi.org/10.1152/ajpgi.00521.2010" @default.
• W2152804723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3094145" @default.
• W2152804723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21311026" @default.
• W2152804723 hasPublicationYear "2011" @default.
• W2152804723 type Work @default.
• W2152804723 sameAs 2152804723 @default.
• W2152804723 citedByCount "67" @default.
• W2152804723 countsByYear W21528047232012 @default.
• W2152804723 countsByYear W21528047232013 @default.
• W2152804723 countsByYear W21528047232014 @default.
• W2152804723 countsByYear W21528047232015 @default.
• W2152804723 countsByYear W21528047232016 @default.
• W2152804723 countsByYear W21528047232017 @default.
• W2152804723 countsByYear W21528047232018 @default.
• W2152804723 countsByYear W21528047232019 @default.
• W2152804723 countsByYear W21528047232020 @default.
• W2152804723 countsByYear W21528047232021 @default.
• W2152804723 countsByYear W21528047232022 @default.
• W2152804723 countsByYear W21528047232023 @default.
• W2152804723 crossrefType "journal-article" @default.
• W2152804723 hasAuthorship W2152804723A5020411590 @default.
• W2152804723 hasAuthorship W2152804723A5035114986 @default.
• W2152804723 hasAuthorship W2152804723A5042185667 @default.
• W2152804723 hasAuthorship W2152804723A5062246921 @default.
• W2152804723 hasAuthorship W2152804723A5065348218 @default.
• W2152804723 hasAuthorship W2152804723A5080649327 @default.
• W2152804723 hasBestOaLocation W21528047232 @default.
• W2152804723 hasConcept C103395026 @default.
• W2152804723 hasConcept C104317684 @default.
• W2152804723 hasConcept C13935069 @default.
• W2152804723 hasConcept C149011108 @default.
• W2152804723 hasConcept C170493617 @default.
• W2152804723 hasConcept C185592680 @default.
• W2152804723 hasConcept C2777593968 @default.
• W2152804723 hasConcept C2779281246 @default.
• W2152804723 hasConcept C46699223 @default.
• W2152804723 hasConcept C49039625 @default.
• W2152804723 hasConcept C55493867 @default.
• W2152804723 hasConcept C71315377 @default.
• W2152804723 hasConcept C86803240 @default.
• W2152804723 hasConcept C95444343 @default.
• W2152804723 hasConceptScore W2152804723C103395026 @default.
• W2152804723 hasConceptScore W2152804723C104317684 @default.
• W2152804723 hasConceptScore W2152804723C13935069 @default.
• W2152804723 hasConceptScore W2152804723C149011108 @default.

• next