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• W2152806945 abstract "ABSTRACT Campylobacter jejuni is a globally distributed cause of human food-borne enteritis and has been linked to chronic joint and neurological diseases. We hypothesized that C. jejuni 11168 colonizes the gastrointestinal tract of both C57BL/6 mice and congenic C57BL/6 interleukin-10-deficient (IL-10 −/− ) mice and that C57BL/6 IL-10 −/− mice experience C. jejuni 11168-mediated clinical signs and pathology. Individually housed mice were challenged orally with C. jejuni 11168, and the course of infection was monitored by clinical examination, bacterial culture, C. jejuni -specific PCR, gross pathology, histopathology, immunohistochemistry, and anti- C. jejuni -specific serology. Ceca of C. jejuni 11168-infected mice were colonized at high rates: ceca of 50/50 wild-type mice and 168/170 IL-10 −/− mice were colonized. In a range from 2 to 35 days after infection with C. jejuni 11168, C57BL/6 IL-10 −/− mice developed severe typhlocolitis best evaluated at the ileocecocolic junction. Rates of colonization and enteritis did not differ between male and female mice. A dose-response experiment showed that as little as 10 6 CFU produced significant disease and pathological lesions similar to responses seen in humans. Immunohistochemical staining demonstrated C. jejuni antigens within gastrointestinal tissues of infected mice. Significant anti- C. jejuni plasma immunoglobulin levels developed by day 28 after infection in both wild-type and IL-10-deficient animals; antibodies were predominantly T-helper-cell 1 (Th1)-associated subtypes. These results indicate that the colonization of the mouse gastrointestinal tract by C. jejuni 11168 is necessary but not sufficient for the development of enteritis and that C57BL/6 IL-10 −/− mice can serve as models for the study of C. jejuni enteritis in humans." @default.
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• W2152806945 date "2007-03-01" @default.
• W2152806945 modified "2023-09-26" @default.
• W2152806945 title "C57BL/6 and Congenic Interleukin-10-Deficient Mice Can Serve as Models of<i>Campylobacter jejuni</i>Colonization and Enteritis" @default.
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• W2152806945 doi "https://doi.org/10.1128/iai.00833-06" @default.
• W2152806945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1828563" @default.
• W2152806945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17130251" @default.
• W2152806945 hasPublicationYear "2007" @default.
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