FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152809991> ?p ?o ?g. }

• W2152809991 endingPage "819" @default.
• W2152809991 startingPage "819" @default.
• W2152809991 abstract "A series of 2-anilinonicotinyl linked 1,3,4-oxadiazoles was synthesized and evaluated for their antitumour activity against various cancer cell lines, inhibition of tubulin polymerization and cell cycle effects. Some of these compounds showed good antiproliferative activity with GI50 values ranging from 4.57 to 97.09 μM in the human cancer cell lines and one of the compounds 5m showed potent antitumour efficacy in all the cell lines tested. This compound also inhibited tubulin polymerization under both in vitro and in vivo conditions. Analysis of tubulin by Western blot experiments demonstrated that 5m depolymerizes microtubules by causing disturbances in the ratio of soluble versus polymerized tubulin in cells, leading to the cell cycle arrest at G2/M phase of the cell cycle followed by activation of caspase-3 activity and apoptotic cell death." @default.
• W2152809991 created "2016-06-24" @default.
• W2152809991 creator A5000744999 @default.
• W2152809991 creator A5003446394 @default.
• W2152809991 creator A5004588361 @default.
• W2152809991 creator A5007912788 @default.
• W2152809991 creator A5010907854 @default.
• W2152809991 creator A5028637869 @default.
• W2152809991 creator A5028889608 @default.
• W2152809991 creator A5074071380 @default.
• W2152809991 date "2011-01-01" @default.
• W2152809991 modified "2023-09-28" @default.
• W2152809991 title "2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization" @default.
• W2152809991 cites W1582305847 @default.
• W2152809991 cites W1966649165 @default.
• W2152809991 cites W1967485654 @default.
• W2152809991 cites W1972234313 @default.
• W2152809991 cites W1985099778 @default.
• W2152809991 cites W1985411236 @default.
• W2152809991 cites W1988369885 @default.
• W2152809991 cites W1988518686 @default.
• W2152809991 cites W1990349260 @default.
• W2152809991 cites W2015908647 @default.
• W2152809991 cites W2017440206 @default.
• W2152809991 cites W2019174178 @default.
• W2152809991 cites W2022731314 @default.
• W2152809991 cites W2023638028 @default.
• W2152809991 cites W2023765234 @default.
• W2152809991 cites W2023924866 @default.
• W2152809991 cites W2029914986 @default.
• W2152809991 cites W2032104847 @default.
• W2152809991 cites W2038020133 @default.
• W2152809991 cites W2039647828 @default.
• W2152809991 cites W2048454522 @default.
• W2152809991 cites W2051916700 @default.
• W2152809991 cites W2071386454 @default.
• W2152809991 cites W2072163509 @default.
• W2152809991 cites W2080430954 @default.
• W2152809991 cites W2081503098 @default.
• W2152809991 cites W2090841642 @default.
• W2152809991 cites W2098363622 @default.
• W2152809991 cites W2106521963 @default.
• W2152809991 cites W2134827332 @default.
• W2152809991 cites W2136696130 @default.
• W2152809991 cites W2164157698 @default.
• W2152809991 cites W2324798725 @default.
• W2152809991 cites W2949315853 @default.
• W2152809991 cites W2949505892 @default.
• W2152809991 cites W4247819406 @default.
• W2152809991 doi "https://doi.org/10.1039/c0md00177e" @default.
• W2152809991 hasPublicationYear "2011" @default.
• W2152809991 type Work @default.
• W2152809991 sameAs 2152809991 @default.
• W2152809991 citedByCount "73" @default.
• W2152809991 countsByYear W21528099912012 @default.
• W2152809991 countsByYear W21528099912013 @default.
• W2152809991 countsByYear W21528099912014 @default.
• W2152809991 countsByYear W21528099912015 @default.
• W2152809991 countsByYear W21528099912016 @default.
• W2152809991 countsByYear W21528099912017 @default.
• W2152809991 countsByYear W21528099912018 @default.
• W2152809991 countsByYear W21528099912019 @default.
• W2152809991 countsByYear W21528099912020 @default.
• W2152809991 countsByYear W21528099912021 @default.
• W2152809991 countsByYear W21528099912022 @default.
• W2152809991 crossrefType "journal-article" @default.
• W2152809991 hasAuthorship W2152809991A5000744999 @default.
• W2152809991 hasAuthorship W2152809991A5003446394 @default.
• W2152809991 hasAuthorship W2152809991A5004588361 @default.
• W2152809991 hasAuthorship W2152809991A5007912788 @default.
• W2152809991 hasAuthorship W2152809991A5010907854 @default.
• W2152809991 hasAuthorship W2152809991A5028637869 @default.
• W2152809991 hasAuthorship W2152809991A5028889608 @default.
• W2152809991 hasAuthorship W2152809991A5074071380 @default.
• W2152809991 hasConcept C104317684 @default.
• W2152809991 hasConcept C105696609 @default.
• W2152809991 hasConcept C1491633281 @default.
• W2152809991 hasConcept C178790620 @default.
• W2152809991 hasConcept C185592680 @default.
• W2152809991 hasConcept C190283241 @default.
• W2152809991 hasConcept C202751555 @default.
• W2152809991 hasConcept C20418707 @default.
• W2152809991 hasConcept C207001950 @default.
• W2152809991 hasConcept C2776415932 @default.
• W2152809991 hasConcept C29537977 @default.
• W2152809991 hasConcept C44228677 @default.
• W2152809991 hasConcept C521977710 @default.
• W2152809991 hasConcept C54355233 @default.
• W2152809991 hasConcept C55493867 @default.
• W2152809991 hasConcept C62112901 @default.
• W2152809991 hasConcept C81885089 @default.
• W2152809991 hasConcept C84425145 @default.
• W2152809991 hasConcept C86803240 @default.
• W2152809991 hasConcept C95444343 @default.
• W2152809991 hasConceptScore W2152809991C104317684 @default.
• W2152809991 hasConceptScore W2152809991C105696609 @default.
• W2152809991 hasConceptScore W2152809991C1491633281 @default.
• W2152809991 hasConceptScore W2152809991C178790620 @default.

• next