Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152812135> ?p ?o ?g. }
- W2152812135 endingPage "271" @default.
- W2152812135 startingPage "255" @default.
- W2152812135 abstract "Background: According to the ‘amyloid cascade hypothesis’ of Alzheimer's disease (AD), abnormal processing of beta-amyloid precursor protein (βAPP) into toxic amyloid beta (Aβ)-peptides is central to the etiopathology of this uniquely human brain disorder. Objective: To review current AD drugs, pharmacological approaches and strategies aimed at modulating Aβ-peptide generation and/or aggregation in the treatment of AD. Methods: Data searches at various websites: Alzheimer Research Forum; individual drug company databases; Medline; Pharmaprojects database; unpublished research; inter-University research communications. Results/conclusion: Considerable research effort has focused on secretase-mediated mechanisms of βAPP processing, and the latest pharmacological strategies have used selective Aβ-peptide-lowering agents (SALA) to provide therapeutic benefit against Aβ-initiated neurodegenerative pathology. Currently, dedicated anticholinesterase, glutamatergic agonist and Aβ-peptide immunization have had little impact in the clinical treatment of AD. One unexpected benefit of statins (HMG-CoA inhibitors), besides their cholesterol lowering abilities, has been their ancillary effects in potentiating the enzymatic mechanisms that generate Aβ-peptides. The long-term benefits or complications of statin-based therapies for use in the clinical management of AD are not known." @default.
- W2152812135 created "2016-06-24" @default.
- W2152812135 creator A5034934480 @default.
- W2152812135 date "2008-06-01" @default.
- W2152812135 modified "2023-10-18" @default.
- W2152812135 title "Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)" @default.
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