FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152813709> ?p ?o ?g. }

• W2152813709 endingPage "560" @default.
• W2152813709 startingPage "551" @default.
• W2152813709 abstract "One of the most serious complications faced by patients with inflammatory bowel disease (IBD) is the potential development of colorectal cancer (CRC). There is a compelling need to enhance the accuracy of cancer screening of IBD patients. MicroRNAs (miRNAs) are small nonprotein-coding RNAs that play important roles in CRC oncogenesis. In this study, we report differential miRNA expression in IBD patients with associated CRC from non-neoplastic tissue to dysplasia and eventually cancer. In addition, we identify and examine the role of dysregulated miRNAs in the TP53 pathway. In our CD patients, six miRNAs were upregulated from non-neoplastic tissue to dysplasia, but downregulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143) (P < 0.001). Six differentially expressed miRNAs affected the TP53 pathway (miR-122, miR-214, miR-372, miR-15b, let-7e, miR-17) (P < 0.001). Using two human colon cancer cell lines (HT-29 and HCT-116), E2F1, an upstream regulator of TP53, was downregulated in both cell lines transfected with let-7e (P < 0.05) as well as in HCT-116 cells transfected with miR-17 (P < 0.05). Additionally, cyclin G, a cell-cycle regulator miR-122 target was downregulated in both cell lines (P < 0.05). Unique differentially expressed miRNAs were observed in CD-associated CRC progression. Six of these miRNAs had a tumorigenic effect on the TP53 pathway; the effect of three of which was studied using cell lines. Hum Mutat 33:551–560, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2152813709 created "2016-06-24" @default.
• W2152813709 creator A5002920949 @default.
• W2152813709 creator A5009507765 @default.
• W2152813709 creator A5010871433 @default.
• W2152813709 creator A5025003501 @default.
• W2152813709 creator A5025415335 @default.
• W2152813709 creator A5041814673 @default.
• W2152813709 creator A5043394178 @default.
• W2152813709 creator A5046209577 @default.
• W2152813709 creator A5048522273 @default.
• W2152813709 creator A5067365818 @default.
• W2152813709 creator A5082887069 @default.
• W2152813709 creator A5089715838 @default.
• W2152813709 date "2012-02-14" @default.
• W2152813709 modified "2023-09-24" @default.
• W2152813709 title "Differential MicroRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer" @default.
• W2152813709 cites W1487867498 @default.
• W2152813709 cites W1808026108 @default.
• W2152813709 cites W1900804936 @default.
• W2152813709 cites W1994798484 @default.
• W2152813709 cites W1997035694 @default.
• W2152813709 cites W2008144841 @default.
• W2152813709 cites W2010215928 @default.
• W2152813709 cites W2023945362 @default.
• W2152813709 cites W2040463432 @default.
• W2152813709 cites W2040466567 @default.
• W2152813709 cites W2041226307 @default.
• W2152813709 cites W2057542627 @default.
• W2152813709 cites W2059747767 @default.
• W2152813709 cites W2069942523 @default.
• W2152813709 cites W2074737604 @default.
• W2152813709 cites W2079046187 @default.
• W2152813709 cites W2082770695 @default.
• W2152813709 cites W2087641016 @default.
• W2152813709 cites W2093690138 @default.
• W2152813709 cites W2094635789 @default.
• W2152813709 cites W2104074002 @default.
• W2152813709 cites W2104956231 @default.
• W2152813709 cites W2105546030 @default.
• W2152813709 cites W2106212265 @default.
• W2152813709 cites W2118473681 @default.
• W2152813709 cites W2123603746 @default.
• W2152813709 cites W2130078150 @default.
• W2152813709 cites W2142635246 @default.
• W2152813709 cites W2145352784 @default.
• W2152813709 cites W2148018015 @default.
• W2152813709 cites W2153777306 @default.
• W2152813709 cites W2156178399 @default.
• W2152813709 cites W2157157037 @default.
• W2152813709 cites W2161733605 @default.
• W2152813709 cites W2170281485 @default.
• W2152813709 doi "https://doi.org/10.1002/humu.22021" @default.
• W2152813709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4410875" @default.
• W2152813709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22241525" @default.
• W2152813709 hasPublicationYear "2012" @default.
• W2152813709 type Work @default.
• W2152813709 sameAs 2152813709 @default.
• W2152813709 citedByCount "110" @default.
• W2152813709 countsByYear W21528137092012 @default.
• W2152813709 countsByYear W21528137092013 @default.
• W2152813709 countsByYear W21528137092014 @default.
• W2152813709 countsByYear W21528137092015 @default.
• W2152813709 countsByYear W21528137092016 @default.
• W2152813709 countsByYear W21528137092017 @default.
• W2152813709 countsByYear W21528137092018 @default.
• W2152813709 countsByYear W21528137092019 @default.
• W2152813709 countsByYear W21528137092020 @default.
• W2152813709 countsByYear W21528137092021 @default.
• W2152813709 countsByYear W21528137092022 @default.
• W2152813709 countsByYear W21528137092023 @default.
• W2152813709 crossrefType "journal-article" @default.
• W2152813709 hasAuthorship W2152813709A5002920949 @default.
• W2152813709 hasAuthorship W2152813709A5009507765 @default.
• W2152813709 hasAuthorship W2152813709A5010871433 @default.
• W2152813709 hasAuthorship W2152813709A5025003501 @default.
• W2152813709 hasAuthorship W2152813709A5025415335 @default.
• W2152813709 hasAuthorship W2152813709A5041814673 @default.
• W2152813709 hasAuthorship W2152813709A5043394178 @default.
• W2152813709 hasAuthorship W2152813709A5046209577 @default.
• W2152813709 hasAuthorship W2152813709A5048522273 @default.
• W2152813709 hasAuthorship W2152813709A5067365818 @default.
• W2152813709 hasAuthorship W2152813709A5082887069 @default.
• W2152813709 hasAuthorship W2152813709A5089715838 @default.
• W2152813709 hasBestOaLocation W21528137092 @default.
• W2152813709 hasConcept C104317684 @default.
• W2152813709 hasConcept C121608353 @default.
• W2152813709 hasConcept C126322002 @default.
• W2152813709 hasConcept C127561419 @default.
• W2152813709 hasConcept C145059251 @default.
• W2152813709 hasConcept C199835354 @default.
• W2152813709 hasConcept C2775894508 @default.
• W2152813709 hasConcept C2778260677 @default.
• W2152813709 hasConcept C2779134260 @default.
• W2152813709 hasConcept C29537977 @default.
• W2152813709 hasConcept C502942594 @default.
• W2152813709 hasConcept C526805850 @default.
• W2152813709 hasConcept C54009773 @default.

• next