FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152828327> ?p ?o ?g. }

• W2152828327 endingPage "H1626" @default.
• W2152828327 startingPage "H1618" @default.
• W2152828327 abstract "Emerging evidence suggests that restoration of blood flow in a stuttering manner may limit lethal myocardial ischemia-reperfusion injury. However, the mechanisms contributing to this phenomenon, termed postconditioning (post-C), remain poorly defined. Our aim was to test the hypothesis that activation of classic survival kinases, phosphatidylinositol 3-kinase (PI3-kinase) and/or extracellular signal-regulated kinase (ERK)1/2, may play a role in post-C-induced cardioprotection. In protocol 1, isolated buffer-perfused rabbit hearts underwent 30 min of sustained coronary artery occlusion and were randomized to receive abrupt reperfusion (controls) or four cycles of 30 s of reperfusion and 30 s of reocclusion before full restoration of flow (post-C). Protocol 2 was identical except control and postconditioned hearts received the PI3-kinase inhibitor LY-294002 (protocol 2A) or the ERK1/2 antagonist PD-98059 (protocol 2B) throughout the first 25 min of reperfusion, whereas in protocol 3, myocardial samples were obtained during the early minutes of reflow from additional control, postconditioned, and nonischemic sham hearts for the assessment, by standard immunoblotting, of phospho-Akt (downstream target of PI3-kinase) and phospho-ERK. Protocols 1 and 2 corroborated that infarct size (delineated by tetrazolium staining and expressed as a percent of risk region) was reduced in postconditioned hearts vs. control hearts and also revealed that post-C-induced cardioprotection was maintained despite LY-294002 treatment but was abrogated by PD-98059. These pharmacological data were supported by protocol 3, which showed increased immunoreactivity of phospho-ERK but not phospho-Akt with post-C. Thus our results implicate the involvement of ERK1/2 rather than PI3-kinase/Akt in the reduction of infarct size achieved with post-C." @default.
• W2152828327 created "2016-06-24" @default.
• W2152828327 creator A5006717458 @default.
• W2152828327 creator A5016703876 @default.
• W2152828327 creator A5017018658 @default.
• W2152828327 creator A5058050458 @default.
• W2152828327 creator A5058895155 @default.
• W2152828327 creator A5067376138 @default.
• W2152828327 date "2005-10-01" @default.
• W2152828327 modified "2023-09-30" @default.
• W2152828327 title "Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2" @default.
• W2152828327 cites W153490132 @default.
• W2152828327 cites W1977375646 @default.
• W2152828327 cites W1988451157 @default.
• W2152828327 cites W1988592848 @default.
• W2152828327 cites W2001407497 @default.
• W2152828327 cites W2016837466 @default.
• W2152828327 cites W2028289828 @default.
• W2152828327 cites W2032922750 @default.
• W2152828327 cites W2036579170 @default.
• W2152828327 cites W2044467032 @default.
• W2152828327 cites W2047373489 @default.
• W2152828327 cites W2049043910 @default.
• W2152828327 cites W2061365466 @default.
• W2152828327 cites W2080045599 @default.
• W2152828327 cites W2081663348 @default.
• W2152828327 cites W2087812939 @default.
• W2152828327 cites W2092914889 @default.
• W2152828327 cites W2117344826 @default.
• W2152828327 cites W2120007291 @default.
• W2152828327 cites W2126960465 @default.
• W2152828327 cites W2134704000 @default.
• W2152828327 cites W2137445925 @default.
• W2152828327 cites W2145161465 @default.
• W2152828327 cites W2147791296 @default.
• W2152828327 cites W23083133 @default.
• W2152828327 cites W2354350325 @default.
• W2152828327 cites W2404914521 @default.
• W2152828327 cites W2417306507 @default.
• W2152828327 cites W2442704990 @default.
• W2152828327 cites W2970711 @default.
• W2152828327 doi "https://doi.org/10.1152/ajpheart.00055.2005" @default.
• W2152828327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15937101" @default.
• W2152828327 hasPublicationYear "2005" @default.
• W2152828327 type Work @default.
• W2152828327 sameAs 2152828327 @default.
• W2152828327 citedByCount "195" @default.
• W2152828327 countsByYear W21528283272012 @default.
• W2152828327 countsByYear W21528283272013 @default.
• W2152828327 countsByYear W21528283272014 @default.
• W2152828327 countsByYear W21528283272015 @default.
• W2152828327 countsByYear W21528283272016 @default.
• W2152828327 countsByYear W21528283272017 @default.
• W2152828327 countsByYear W21528283272018 @default.
• W2152828327 countsByYear W21528283272019 @default.
• W2152828327 countsByYear W21528283272020 @default.
• W2152828327 countsByYear W21528283272021 @default.
• W2152828327 countsByYear W21528283272022 @default.
• W2152828327 crossrefType "journal-article" @default.
• W2152828327 hasAuthorship W2152828327A5006717458 @default.
• W2152828327 hasAuthorship W2152828327A5016703876 @default.
• W2152828327 hasAuthorship W2152828327A5017018658 @default.
• W2152828327 hasAuthorship W2152828327A5058050458 @default.
• W2152828327 hasAuthorship W2152828327A5058895155 @default.
• W2152828327 hasAuthorship W2152828327A5067376138 @default.
• W2152828327 hasConcept C126322002 @default.
• W2152828327 hasConcept C164705383 @default.
• W2152828327 hasConcept C184235292 @default.
• W2152828327 hasConcept C2779676291 @default.
• W2152828327 hasConcept C2780114680 @default.
• W2152828327 hasConcept C42219234 @default.
• W2152828327 hasConcept C500558357 @default.
• W2152828327 hasConcept C541997718 @default.
• W2152828327 hasConcept C57074206 @default.
• W2152828327 hasConcept C62478195 @default.
• W2152828327 hasConcept C71924100 @default.
• W2152828327 hasConcept C75217442 @default.
• W2152828327 hasConcept C86803240 @default.
• W2152828327 hasConcept C95444343 @default.
• W2152828327 hasConceptScore W2152828327C126322002 @default.
• W2152828327 hasConceptScore W2152828327C164705383 @default.
• W2152828327 hasConceptScore W2152828327C184235292 @default.
• W2152828327 hasConceptScore W2152828327C2779676291 @default.
• W2152828327 hasConceptScore W2152828327C2780114680 @default.
• W2152828327 hasConceptScore W2152828327C42219234 @default.
• W2152828327 hasConceptScore W2152828327C500558357 @default.
• W2152828327 hasConceptScore W2152828327C541997718 @default.
• W2152828327 hasConceptScore W2152828327C57074206 @default.
• W2152828327 hasConceptScore W2152828327C62478195 @default.
• W2152828327 hasConceptScore W2152828327C71924100 @default.
• W2152828327 hasConceptScore W2152828327C75217442 @default.
• W2152828327 hasConceptScore W2152828327C86803240 @default.
• W2152828327 hasConceptScore W2152828327C95444343 @default.
• W2152828327 hasIssue "4" @default.
• W2152828327 hasLocation W21528283271 @default.
• W2152828327 hasLocation W21528283272 @default.
• W2152828327 hasOpenAccess W2152828327 @default.
• W2152828327 hasPrimaryLocation W21528283271 @default.

• next