FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152835229> ?p ?o ?g. }

• W2152835229 endingPage "2117" @default.
• W2152835229 startingPage "2105" @default.
• W2152835229 abstract "Chronic kidney disease is a major contributor to human and companion animal morbidity and mortality. Renal complications are sequelae of canine and human visceral leishmaniasis (VL). Despite the high incidence of infection-mediated glomerulonephritis, little is known about pathogenesis of VL-associated renal disease. Leishmania infantum-infected dogs are a naturally occurring model of VL-associated glomerulonephritis. Membranoproliferative glomerulonephritis type I [24 of 25 (96%)], with interstitial lymphoplasmacytic nephritis [23 of 25 (92%)], and glomerular and interstitial fibrosis [12 of 25 (48%)] were predominant lesions. An ultrastructural evaluation of glomeruli from animals with VL identified mesangial cell proliferation and interposition. Immunohistochemistry demonstrated significant Leishmania antigen, IgG, and C3b deposition in VL dog glomeruli. Asymptomatic and symptomatic dogs had increased glomerular nucleotide-binding domain leucine-rich repeat-containing-like receptor family, pyrin domain containing 3 and autophagosome-associated microtubule-associated protein 1 light chain 3 associated with glomerular lesion severity. Transcriptional analyses from symptomatic dogs confirmed induction of autophagy and inflammasome genes within glomeruli and tubules. On the basis of temporal VL staging, glomerulonephritis was initiated by IgG and complement deposition. This deposition preceded presence of nucleotide-binding domain leucine-rich repeat-containing-like receptor family, pyrin domain containing 3-associated inflammasomes and increased light chain 3 puncta indicative of autophagosomes in glomeruli from dogs with clinical VL and renal failure. These findings indicate potential roles for inflammasome complexes in glomerular damage during VL and autophagy in ensuing cellular responses." @default.
• W2152835229 created "2016-06-24" @default.
• W2152835229 creator A5000031933 @default.
• W2152835229 creator A5018235680 @default.
• W2152835229 creator A5020113147 @default.
• W2152835229 creator A5022440739 @default.
• W2152835229 creator A5023056980 @default.
• W2152835229 creator A5034290033 @default.
• W2152835229 creator A5046703302 @default.
• W2152835229 creator A5049341817 @default.
• W2152835229 creator A5054863009 @default.
• W2152835229 creator A5072211893 @default.
• W2152835229 creator A5087431436 @default.
• W2152835229 date "2015-08-01" @default.
• W2152835229 modified "2023-10-11" @default.
• W2152835229 title "Activation of Autophagy and Nucleotide-Binding Domain Leucine-Rich Repeat–Containing-Like Receptor Family, Pyrin Domain–Containing 3 Inflammasome during Leishmania infantum–Associated Glomerulonephritis" @default.
• W2152835229 cites W119159189 @default.
• W2152835229 cites W1256238550 @default.
• W2152835229 cites W1569584355 @default.
• W2152835229 cites W1636793459 @default.
• W2152835229 cites W1821968665 @default.
• W2152835229 cites W1927491384 @default.
• W2152835229 cites W1959874120 @default.
• W2152835229 cites W1974412717 @default.
• W2152835229 cites W1987769185 @default.
• W2152835229 cites W1992113146 @default.
• W2152835229 cites W1992300913 @default.
• W2152835229 cites W1992625198 @default.
• W2152835229 cites W1992931917 @default.
• W2152835229 cites W1993932802 @default.
• W2152835229 cites W1996024251 @default.
• W2152835229 cites W1997314757 @default.
• W2152835229 cites W1998399313 @default.
• W2152835229 cites W2009004909 @default.
• W2152835229 cites W2009255343 @default.
• W2152835229 cites W2009800174 @default.
• W2152835229 cites W2011951509 @default.
• W2152835229 cites W2016741118 @default.
• W2152835229 cites W2018418660 @default.
• W2152835229 cites W2020260798 @default.
• W2152835229 cites W2021988356 @default.
• W2152835229 cites W2029220328 @default.
• W2152835229 cites W2041561635 @default.
• W2152835229 cites W2050449334 @default.
• W2152835229 cites W2050834222 @default.
• W2152835229 cites W2050953001 @default.
• W2152835229 cites W2051043379 @default.
• W2152835229 cites W2060555951 @default.
• W2152835229 cites W2065031087 @default.
• W2152835229 cites W2077994995 @default.
• W2152835229 cites W2078554556 @default.
• W2152835229 cites W2080717362 @default.
• W2152835229 cites W2086197089 @default.
• W2152835229 cites W2088140877 @default.
• W2152835229 cites W2088149495 @default.
• W2152835229 cites W2095999453 @default.
• W2152835229 cites W2107277218 @default.
• W2152835229 cites W2109600120 @default.
• W2152835229 cites W2111994713 @default.
• W2152835229 cites W2122942994 @default.
• W2152835229 cites W2133391754 @default.
• W2152835229 cites W2134143044 @default.
• W2152835229 cites W2136050048 @default.
• W2152835229 cites W2139926426 @default.
• W2152835229 cites W2141516858 @default.
• W2152835229 cites W2143730240 @default.
• W2152835229 cites W2157650174 @default.
• W2152835229 cites W2169856031 @default.
• W2152835229 cites W2170192068 @default.
• W2152835229 cites W2192080449 @default.
• W2152835229 cites W2280057432 @default.
• W2152835229 cites W2317166160 @default.
• W2152835229 cites W2396981871 @default.
• W2152835229 cites W2411285851 @default.
• W2152835229 cites W303939549 @default.
• W2152835229 cites W4295334685 @default.
• W2152835229 doi "https://doi.org/10.1016/j.ajpath.2015.04.017" @default.
• W2152835229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4530124" @default.
• W2152835229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26079813" @default.
• W2152835229 hasPublicationYear "2015" @default.
• W2152835229 type Work @default.
• W2152835229 sameAs 2152835229 @default.
• W2152835229 citedByCount "32" @default.
• W2152835229 countsByYear W21528352292016 @default.
• W2152835229 countsByYear W21528352292017 @default.
• W2152835229 countsByYear W21528352292018 @default.
• W2152835229 countsByYear W21528352292019 @default.
• W2152835229 countsByYear W21528352292020 @default.
• W2152835229 countsByYear W21528352292021 @default.
• W2152835229 countsByYear W21528352292022 @default.
• W2152835229 countsByYear W21528352292023 @default.
• W2152835229 crossrefType "journal-article" @default.
• W2152835229 hasAuthorship W2152835229A5000031933 @default.
• W2152835229 hasAuthorship W2152835229A5018235680 @default.
• W2152835229 hasAuthorship W2152835229A5020113147 @default.
• W2152835229 hasAuthorship W2152835229A5022440739 @default.
• W2152835229 hasAuthorship W2152835229A5023056980 @default.
• W2152835229 hasAuthorship W2152835229A5034290033 @default.

• next