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- W2152837700 abstract "Significance Carbohydrates (glycans) are complex cell surface molecules that control multiple aspects of cell biology, including cell–cell communication, cancer metastasis, and inflammation. Glycan biosynthesis requires the coordination of many enzymes, but how this is regulated is not well understood. Herein we show that microRNA (miRNA), small noncoding RNA, are a major regulator of cell surface glycosylation. We map miRNA expression onto carbohydrate signatures obtained by using lectin microarrays, a glycan analysis method. We identify and validate several miRNA–glycan networks, including a major decision point in N -linked glycan biosynthesis. Overall, our work provides insights into the “black box” of carbohydrate control mechanisms." @default.
- W2152837700 created "2016-06-24" @default.
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- W2152837700 date "2014-03-03" @default.
- W2152837700 modified "2023-10-14" @default.
- W2152837700 title "Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode" @default.
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- W2152837700 doi "https://doi.org/10.1073/pnas.1321524111" @default.
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