FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152841529> ?p ?o ?g. }

• W2152841529 endingPage "81" @default.
• W2152841529 startingPage "577" @default.
• W2152841529 abstract "There is a continued need for orally bioavailable anticancer compounds that exhibit good efficacy against breast cancer. STX140, a derivative of 2-methoxyestradiol (2-MeOE2), has been shown to have excellent oral bioavailability and significantly reduces tumor growth. A new micronized formulation of STX140 has now been developed and its pharmacokinetics (PK) in rats and effect on MDA-MB-231 breast cancer growth in nude mice was investigated.For the PK studies, female Wistar rats were treated orally with STX140 in two separate vehicles (10% tetrahydrofuran (THF) in propylene glycol (PG) or 0.5% methyl cellulose (MC) in saline) and plasma samples taken for high performance liquid chromatography analysis over 48 h. For the tumor efficacy studies, female nude mice were inoculated with MDA-MB-231 breast cancer cells and then treated orally with a range of doses of STX140.The PK studies demonstrated that the THF/PG vehicle resulted in a greater oral bioavailability of STX140 compared to the 0.5% MC vehicle. However, this was not translated to the tumor efficacy studies where STX140 at 20 mg/kg in either vehicle caused a significant reduction in tumor volume.The new micronized formulation of STX140 is orally bioavailable and efficacious at inhibiting MDA-MB-231 breast tumor growth." @default.
• W2152841529 created "2016-06-24" @default.
• W2152841529 creator A5004708346 @default.
• W2152841529 creator A5006992138 @default.
• W2152841529 creator A5013687413 @default.
• W2152841529 creator A5027171542 @default.
• W2152841529 creator A5055207921 @default.
• W2152841529 creator A5057398969 @default.
• W2152841529 creator A5067225147 @default.
• W2152841529 creator A5070625271 @default.
• W2152841529 creator A5072242079 @default.
• W2152841529 creator A5082393921 @default.
• W2152841529 creator A5083786929 @default.
• W2152841529 creator A5088990837 @default.
• W2152841529 date "2008-05-30" @default.
• W2152841529 modified "2023-09-27" @default.
• W2152841529 title "A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer." @default.
• W2152841529 cites W1502777806 @default.
• W2152841529 cites W1758017998 @default.
• W2152841529 cites W1964485062 @default.
• W2152841529 cites W1974744898 @default.
• W2152841529 cites W2003292783 @default.
• W2152841529 cites W2015662278 @default.
• W2152841529 cites W2048132932 @default.
• W2152841529 cites W2055344124 @default.
• W2152841529 cites W2058484250 @default.
• W2152841529 cites W2062204672 @default.
• W2152841529 cites W2085463235 @default.
• W2152841529 cites W2087065591 @default.
• W2152841529 cites W2106787323 @default.
• W2152841529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18506995" @default.
• W2152841529 hasPublicationYear "2008" @default.
• W2152841529 type Work @default.
• W2152841529 sameAs 2152841529 @default.
• W2152841529 citedByCount "6" @default.
• W2152841529 countsByYear W21528415292012 @default.
• W2152841529 countsByYear W21528415292017 @default.
• W2152841529 countsByYear W21528415292021 @default.
• W2152841529 countsByYear W21528415292023 @default.
• W2152841529 crossrefType "journal-article" @default.
• W2152841529 hasAuthorship W2152841529A5004708346 @default.
• W2152841529 hasAuthorship W2152841529A5006992138 @default.
• W2152841529 hasAuthorship W2152841529A5013687413 @default.
• W2152841529 hasAuthorship W2152841529A5027171542 @default.
• W2152841529 hasAuthorship W2152841529A5055207921 @default.
• W2152841529 hasAuthorship W2152841529A5057398969 @default.
• W2152841529 hasAuthorship W2152841529A5067225147 @default.
• W2152841529 hasAuthorship W2152841529A5070625271 @default.
• W2152841529 hasAuthorship W2152841529A5072242079 @default.
• W2152841529 hasAuthorship W2152841529A5082393921 @default.
• W2152841529 hasAuthorship W2152841529A5083786929 @default.
• W2152841529 hasAuthorship W2152841529A5088990837 @default.
• W2152841529 hasConcept C112705442 @default.
• W2152841529 hasConcept C121608353 @default.
• W2152841529 hasConcept C126322002 @default.
• W2152841529 hasConcept C181389837 @default.
• W2152841529 hasConcept C185592680 @default.
• W2152841529 hasConcept C2776260442 @default.
• W2152841529 hasConcept C2777056448 @default.
• W2152841529 hasConcept C2777477808 @default.
• W2152841529 hasConcept C530470458 @default.
• W2152841529 hasConcept C55493867 @default.
• W2152841529 hasConcept C71924100 @default.
• W2152841529 hasConcept C98274493 @default.
• W2152841529 hasConceptScore W2152841529C112705442 @default.
• W2152841529 hasConceptScore W2152841529C121608353 @default.
• W2152841529 hasConceptScore W2152841529C126322002 @default.
• W2152841529 hasConceptScore W2152841529C181389837 @default.
• W2152841529 hasConceptScore W2152841529C185592680 @default.
• W2152841529 hasConceptScore W2152841529C2776260442 @default.
• W2152841529 hasConceptScore W2152841529C2777056448 @default.
• W2152841529 hasConceptScore W2152841529C2777477808 @default.
• W2152841529 hasConceptScore W2152841529C530470458 @default.
• W2152841529 hasConceptScore W2152841529C55493867 @default.
• W2152841529 hasConceptScore W2152841529C71924100 @default.
• W2152841529 hasConceptScore W2152841529C98274493 @default.
• W2152841529 hasIssue "2A" @default.
• W2152841529 hasLocation W21528415291 @default.
• W2152841529 hasOpenAccess W2152841529 @default.
• W2152841529 hasPrimaryLocation W21528415291 @default.
• W2152841529 hasRelatedWork W1966108836 @default.
• W2152841529 hasRelatedWork W1968897103 @default.
• W2152841529 hasRelatedWork W1974744898 @default.
• W2152841529 hasRelatedWork W1975784580 @default.
• W2152841529 hasRelatedWork W1989989204 @default.
• W2152841529 hasRelatedWork W1995667035 @default.
• W2152841529 hasRelatedWork W2017999009 @default.
• W2152841529 hasRelatedWork W2027298131 @default.
• W2152841529 hasRelatedWork W2031249491 @default.
• W2152841529 hasRelatedWork W2043670187 @default.
• W2152841529 hasRelatedWork W2048132932 @default.
• W2152841529 hasRelatedWork W2051273138 @default.
• W2152841529 hasRelatedWork W2055344124 @default.
• W2152841529 hasRelatedWork W2057875214 @default.
• W2152841529 hasRelatedWork W2058484250 @default.
• W2152841529 hasRelatedWork W2085993615 @default.
• W2152841529 hasRelatedWork W2087065591 @default.
• W2152841529 hasRelatedWork W2118784523 @default.

• next