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• W2152851578 endingPage "8079" @default.
• W2152851578 startingPage "8069" @default.
• W2152851578 abstract "ABSTRACT Recent studies have shown that the ubiquitin (Ub) proteasome pathway (UPP) is closely related to immune defense. We have identified a ubiquitin-conjugating enzyme, E2, from the Chinese white shrimp, Fenneropenaeus chinensis (FcUbc). Injection of recombinant FcUbc protein (rFcUbc) reduced the mortality of shrimp infected with white spot syndrome virus (WSSV) and inhibited replication of WSSV. rFcUbc, but not a mutant FcUbc (mFcUbc), bound to WSSV RING domains (WRDs) from four potential E3 ligase proteins of WSSV in vitro . Importantly, rFcUbc could ubiquitinate the RING domains (named WRD2 and WRD3) of WSSV277 and WSSV304 proteins in vitro and the two proteins in WSSV-infected Drosophila melanogaster Schneider 2 (S2) cells. Furthermore, overexpression of FcUbc increased ubiquitination of WSSV277 and WSSV304 during WSSV infection. In summary, our study demonstrates that FcUbc from Chinese white shrimp inhibited WSSV replication and could ubiquitinate WSSV RING domain-containing proteins. This is the first report about antiviral function of Ubc E2 in shrimp." @default.
• W2152851578 created "2016-06-24" @default.
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• W2152851578 date "2011-08-15" @default.
• W2152851578 modified "2023-10-18" @default.
• W2152851578 title "Enzyme E2 from Chinese White Shrimp Inhibits Replication of White Spot Syndrome Virus and Ubiquitinates Its RING Domain Proteins" @default.
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• W2152851578 doi "https://doi.org/10.1128/jvi.00487-11" @default.
• W2152851578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3147975" @default.
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