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• W2152853164 endingPage "e3176" @default.
• W2152853164 startingPage "e3176" @default.
• W2152853164 abstract "Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.The T. rangeli haploid genome is ∼ 24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heat-shock proteins.Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets." @default.
• W2152853164 created "2016-06-24" @default.
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• W2152853164 date "2014-09-18" @default.
• W2152853164 modified "2023-10-18" @default.
• W2152853164 title "Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli" @default.
• W2152853164 cites W1482372215 @default.
• W2152853164 cites W1487790589 @default.
• W2152853164 cites W1592463599 @default.
• W2152853164 cites W1766675874 @default.
• W2152853164 cites W1833088140 @default.
• W2152853164 cites W1942695313 @default.
• W2152853164 cites W1968002799 @default.
• W2152853164 cites W1969528909 @default.
• W2152853164 cites W1970607594 @default.
• W2152853164 cites W1977566102 @default.
• W2152853164 cites W1978426257 @default.
• W2152853164 cites W1978754000 @default.
• W2152853164 cites W1978981032 @default.
• W2152853164 cites W1979628965 @default.
• W2152853164 cites W1983242241 @default.
• W2152853164 cites W1985394274 @default.
• W2152853164 cites W1986103093 @default.
• W2152853164 cites W1991977234 @default.
• W2152853164 cites W1992379594 @default.
• W2152853164 cites W1996120416 @default.
• W2152853164 cites W1997323235 @default.
• W2152853164 cites W1998366615 @default.
• W2152853164 cites W1999300802 @default.
• W2152853164 cites W2002840394 @default.
• W2152853164 cites W2002994363 @default.
• W2152853164 cites W2003113505 @default.
• W2152853164 cites W2003262161 @default.
• W2152853164 cites W2004461361 @default.
• W2152853164 cites W2008006175 @default.
• W2152853164 cites W2008544906 @default.
• W2152853164 cites W2009154460 @default.
• W2152853164 cites W2010381501 @default.
• W2152853164 cites W2011265797 @default.
• W2152853164 cites W2012111404 @default.
• W2152853164 cites W2012998817 @default.
• W2152853164 cites W2014445501 @default.
• W2152853164 cites W2014565441 @default.
• W2152853164 cites W2017383643 @default.
• W2152853164 cites W2017732895 @default.
• W2152853164 cites W2020421560 @default.
• W2152853164 cites W2021136660 @default.
• W2152853164 cites W2021679245 @default.
• W2152853164 cites W2026800263 @default.
• W2152853164 cites W2028332568 @default.
• W2152853164 cites W2028786257 @default.
• W2152853164 cites W2034325006 @default.
• W2152853164 cites W2034767282 @default.
• W2152853164 cites W2036615674 @default.
• W2152853164 cites W2036910636 @default.
• W2152853164 cites W2040751953 @default.
• W2152853164 cites W2047826668 @default.
• W2152853164 cites W2047880439 @default.
• W2152853164 cites W2049465499 @default.
• W2152853164 cites W2050878024 @default.
• W2152853164 cites W2052578371 @default.
• W2152853164 cites W2054430816 @default.

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