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- W2152872319 endingPage "511" @default.
- W2152872319 startingPage "503" @default.
- W2152872319 abstract "Summary Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis. In addition, this 340 kD glycoprotein is a stress inducible protein; its synthesis is dramatically upregulated during inflammation or under exposure to stress such systemic infections.This regulation of Fg expression indicates that Fg also participates in the host defense system against infections. In fact, a number of reported studies have demonstrated the involvement of both the intrinsic and extrinsic pathways of coagulation; the thrombotic and the fibrinolytic systems in the pathophysiology of infectious diseases. It is, therefore, perhaps not surprising that many pathogenic bacteria can interact with Fg and manipulate its biology.This review focuses on the major Fg-binding proteins (Fgbps) from Gram-positive bacteria with an emphasis on those that are known to have an effect on coagulation and thrombosis" @default.
- W2152872319 created "2016-06-24" @default.
- W2152872319 creator A5018841163 @default.
- W2152872319 creator A5061892009 @default.
- W2152872319 creator A5062527254 @default.
- W2152872319 creator A5080423083 @default.
- W2152872319 date "2007-01-01" @default.
- W2152872319 modified "2023-10-18" @default.
- W2152872319 title "Fibrinogen-binding proteins of Gram-positive bacteria" @default.
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