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• W2152893102 abstract "Naja naja karachiensis envenomation was found to hit more drastically heart, liver, and kidneys. 400 μ g/kg of venom-raised moderate serum levels of ALT (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>72</mml:mn><mml:mo>±</mml:mo><mml:mn>4.70</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>0.1</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.05</mml:mn></mml:math>), AST (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn>157</mml:mn><mml:mo>±</mml:mo><mml:mn>24.24</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn>0.1</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.05</mml:mn></mml:math>), urea (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mn>42</mml:mn><mml:mo>±</mml:mo><mml:mn>3.08</mml:mn></mml:math> mg/dL,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mn>0.05</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.02</mml:mn></mml:math>), creatinine (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mn>1.74</mml:mn><mml:mo>±</mml:mo><mml:mn>0.03</mml:mn></mml:math> mg/dL,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mn>0.01</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.001</mml:mn></mml:math>), CK-MB (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mn mathvariant=normal>21</mml:mn><mml:mo>±</mml:mo><mml:mn mathvariant=normal>1.5</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mn>0.05</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.02</mml:mn></mml:math>), and LDH (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mn>2064</mml:mn><mml:mo>±</mml:mo><mml:mn>15.98</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>) were injected in experimental rabbits. However, lethality was enhanced with 800 μ g/kg of venom in terms of significant release of ALT (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mn>86</mml:mn><mml:mo>±</mml:mo><mml:mn>5.0</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mn>0.05</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.02</mml:mn></mml:math>), AST (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mn>251</mml:mn><mml:mo>±</mml:mo><mml:mn>18.2</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mn>0.01</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.001</mml:mn></mml:math>), urea (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mn>57.6</mml:mn><mml:mo>±</mml:mo><mml:mn>3.84</mml:mn></mml:math> mg/dL,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M18><mml:mn>0.02</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.01</mml:mn></mml:math>), creatinine (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M19><mml:mn>2.1</mml:mn><mml:mo>±</mml:mo><mml:mn>0.10</mml:mn></mml:math> mg/dL,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M20><mml:mn>0.02</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.01</mml:mn></mml:math>), CK-MB (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M21><mml:mn>77</mml:mn><mml:mo>±</mml:mo><mml:mn>11.22</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M22><mml:mn>0.05</mml:mn><mml:mo>></mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.02</mml:mn></mml:math>), and LDH (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M23><mml:mn>2562</mml:mn><mml:mo>±</mml:mo><mml:mn>25.14</mml:mn></mml:math> U/L,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M24><mml:mi>P</mml:mi><mml:mo>≪</mml:mo><mml:mn>0.001</mml:mn></mml:math>). Among twenty-eight tested medicinal plant extracts, only Stenolobium stans (L.) Seem was found the best antivenom (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M25><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.5</mml:mn></mml:math>) compared to the efficacy of standard antidote (ALT<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M26><mml:mo>=</mml:mo><mml:mn>52.5</mml:mn><mml:mo>±</mml:mo><mml:mn>3.51</mml:mn></mml:math> U/L, AST<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M27><mml:mo>=</mml:mo><mml:mn>69.5</mml:mn><mml:mo>±</mml:mo><mml:mn>18.55</mml:mn></mml:math> U/L, urea<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M28><mml:mo>=</mml:mo><mml:mn>31.5</mml:mn><mml:mo>±</mml:mo><mml:mn>0.50</mml:mn></mml:math> mg/dL, creatinine<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M29><mml:mo>=</mml:mo><mml:mn>1.08</mml:mn><mml:mo>±</mml:mo><mml:mn>0.02</mml:mn></mml:math> mg/dL, CK-MB<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M30><mml:mo>=</mml:mo><mml:mn>09</mml:mn><mml:mo>±</mml:mo><mml:mn>0.85</mml:mn></mml:math> U/L, and LDH<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M31><mml:mo>=</mml:mo><mml:mn>763</mml:mn><mml:mo>±</mml:mo><mml:mn>6.01</mml:mn></mml:math> U/L). Other plant extracts were proved less beneficial and partly neutralized the toxicities posed by cobra venom. However, it is essential in future to isolate and characterize bioactive compound(s) from Stenolobium stans (L.) Seem extract to overcome the complications of snake bite." @default.
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• W2152893102 date "2014-01-01" @default.
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• W2152893102 title "<i>Naja naja karachiensis</i>Envenomation: Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants" @default.
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