FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152895874> ?p ?o ?g. }

• W2152895874 endingPage "4594" @default.
• W2152895874 startingPage "4575" @default.
• W2152895874 abstract "The interferon consensus sequence binding protein (ICSBP) is an interferon regulatory transcription factor, also referred to as IRF8. ICSBP acts as a suppressor of myeloid leukemia, although few target genes explaining this effect have been identified. In the current studies, we identified the gene encoding growth arrest specific 2 (GAS2) as an ICSBP target gene relevant to leukemia suppression. We find that ICSBP, Tel, and histone deacetylase 3 (HDAC3) bind to a cis element in the GAS2 promoter and repress transcription in myeloid progenitor cells. Gas2 inhibits calpain protease activity, and β-catenin is a calpain substrate in these cells. Consistent with this, ICSBP decreases β-catenin protein and activity in a Gas2- and calpain-dependent manner. Conversely, decreased ICSBP expression increases β-catenin protein and activity by the same mechanism. This is of interest, because decreased ICSBP expression and increased β-catenin activity are associated with poor prognosis and blast crisis in chronic myeloid leukemia (CML). We find that the expression of Bcr/abl (the CML oncoprotein) increases Gas2 expression in an ICSBP-dependent manner. This results in decreased calpain activity and a consequent increase in β-catenin activity in Bcr/abl-positive (Bcr/abl+) cells. Therefore, these studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences β-catenin activity in myeloid leukemia." @default.
• W2152895874 created "2016-06-24" @default.
• W2152895874 creator A5030435831 @default.
• W2152895874 creator A5041475657 @default.
• W2152895874 creator A5051335860 @default.
• W2152895874 creator A5075590796 @default.
• W2152895874 creator A5079002879 @default.
• W2152895874 creator A5080043453 @default.
• W2152895874 creator A5082482326 @default.
• W2152895874 creator A5089399049 @default.
• W2152895874 date "2010-10-01" @default.
• W2152895874 modified "2023-09-28" @default.
• W2152895874 title "Interferon Consensus Sequence Binding Protein (ICSBP) Decreases β-Catenin Activity in Myeloid Cells by Repressing <i>GAS2</i> Transcription" @default.
• W2152895874 cites W1516085090 @default.
• W2152895874 cites W1517031547 @default.
• W2152895874 cites W1520290955 @default.
• W2152895874 cites W1548081699 @default.
• W2152895874 cites W1591354332 @default.
• W2152895874 cites W1857506864 @default.
• W2152895874 cites W1965694516 @default.
• W2152895874 cites W1977621555 @default.
• W2152895874 cites W1983717821 @default.
• W2152895874 cites W1986282671 @default.
• W2152895874 cites W1997966826 @default.
• W2152895874 cites W2004608668 @default.
• W2152895874 cites W2008188428 @default.
• W2152895874 cites W2008228521 @default.
• W2152895874 cites W2012962381 @default.
• W2152895874 cites W2018221796 @default.
• W2152895874 cites W2024356977 @default.
• W2152895874 cites W2029438521 @default.
• W2152895874 cites W2031321792 @default.
• W2152895874 cites W2036998973 @default.
• W2152895874 cites W2046516893 @default.
• W2152895874 cites W2048515321 @default.
• W2152895874 cites W2050268640 @default.
• W2152895874 cites W2064641233 @default.
• W2152895874 cites W2080275017 @default.
• W2152895874 cites W2081613861 @default.
• W2152895874 cites W2082820433 @default.
• W2152895874 cites W2096038076 @default.
• W2152895874 cites W2105248205 @default.
• W2152895874 cites W2107268345 @default.
• W2152895874 cites W2116294754 @default.
• W2152895874 cites W2123280495 @default.
• W2152895874 cites W2146167376 @default.
• W2152895874 cites W2154856176 @default.
• W2152895874 cites W2161028989 @default.
• W2152895874 cites W2169523531 @default.
• W2152895874 cites W2259346194 @default.
• W2152895874 cites W4236025207 @default.
• W2152895874 cites W4313342474 @default.
• W2152895874 doi "https://doi.org/10.1128/mcb.01595-09" @default.
• W2152895874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2950519" @default.
• W2152895874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20679491" @default.
• W2152895874 hasPublicationYear "2010" @default.
• W2152895874 type Work @default.
• W2152895874 sameAs 2152895874 @default.
• W2152895874 citedByCount "44" @default.
• W2152895874 countsByYear W21528958742012 @default.
• W2152895874 countsByYear W21528958742013 @default.
• W2152895874 countsByYear W21528958742014 @default.
• W2152895874 countsByYear W21528958742015 @default.
• W2152895874 countsByYear W21528958742016 @default.
• W2152895874 countsByYear W21528958742017 @default.
• W2152895874 countsByYear W21528958742018 @default.
• W2152895874 countsByYear W21528958742020 @default.
• W2152895874 countsByYear W21528958742022 @default.
• W2152895874 countsByYear W21528958742023 @default.
• W2152895874 crossrefType "journal-article" @default.
• W2152895874 hasAuthorship W2152895874A5030435831 @default.
• W2152895874 hasAuthorship W2152895874A5041475657 @default.
• W2152895874 hasAuthorship W2152895874A5051335860 @default.
• W2152895874 hasAuthorship W2152895874A5075590796 @default.
• W2152895874 hasAuthorship W2152895874A5079002879 @default.
• W2152895874 hasAuthorship W2152895874A5080043453 @default.
• W2152895874 hasAuthorship W2152895874A5082482326 @default.
• W2152895874 hasAuthorship W2152895874A5089399049 @default.
• W2152895874 hasBestOaLocation W21528958741 @default.
• W2152895874 hasConcept C104317684 @default.
• W2152895874 hasConcept C117705580 @default.
• W2152895874 hasConcept C2778729363 @default.
• W2152895874 hasConcept C2779282312 @default.
• W2152895874 hasConcept C502942594 @default.
• W2152895874 hasConcept C54355233 @default.
• W2152895874 hasConcept C86339819 @default.
• W2152895874 hasConcept C86803240 @default.
• W2152895874 hasConceptScore W2152895874C104317684 @default.
• W2152895874 hasConceptScore W2152895874C117705580 @default.
• W2152895874 hasConceptScore W2152895874C2778729363 @default.
• W2152895874 hasConceptScore W2152895874C2779282312 @default.
• W2152895874 hasConceptScore W2152895874C502942594 @default.
• W2152895874 hasConceptScore W2152895874C54355233 @default.
• W2152895874 hasConceptScore W2152895874C86339819 @default.
• W2152895874 hasConceptScore W2152895874C86803240 @default.
• W2152895874 hasIssue "19" @default.
• W2152895874 hasLocation W21528958741 @default.
• W2152895874 hasLocation W21528958742 @default.

• next