Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152912193> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2152912193 endingPage "217" @default.
- W2152912193 startingPage "195" @default.
- W2152912193 abstract "Xanthine oxidase (XO) is a highly versatile flavoprotein enzyme, ubiquitous among species (from bacteria to human) and within the various tissues of mammals. The enzyme catalyses the oxidative hydroxylation of purine substrates at the molybdenum centre (the reductive half-reaction) and subsequent reduction of O2 at the flavin centre with generation of reactive oxygen species (ROS), either superoxide anion radical or hydrogen peroxide (the oxidative half-reaction). Many diseases, or at least symptoms of diseases, arise from a deficiency or excess of a specific metabolite in the body. For an example of an excess of a particular metabolite that produces a disease state is the excess of uric acid which can led to gout. Inhibition of XO decreases the uric acid levels, and results in an antihyperuricemic effect. Allopurinol, first synthesised as a potential anticancer agent, is nowadays a clinically useful xanthine oxidase inhibitor used in the treatment of gout. There is overwhelming acceptance that xanthine oxidase serum levels are significantly increased in various pathological states like hepatitis, inflammation, ischemia-reperfusion, carcinogenesis and aging and that ROS generated in the enzymatic process are involved in oxidative damage. Thus, it may be possible that the inhibition of this enzymatic pathway would be beneficial. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the enzyme, associated pathological states, and in the efforts made towards the development of new xanthine oxidase inhibitors. Keywords: Xanthine Oxidase Inhibitors, Xanthine oxidase (XO), xanthine dehydrogenase, uric acid, hyperuricemia, gout, oxidative stress, allopurinol, xanthine, oxidase inhibitors" @default.
- W2152912193 created "2016-06-24" @default.
- W2152912193 creator A5003956314 @default.
- W2152912193 creator A5031955097 @default.
- W2152912193 creator A5068000809 @default.
- W2152912193 date "2002-01-01" @default.
- W2152912193 modified "2023-10-16" @default.
- W2152912193 title "Progress Towards the Discovery of Xanthine Oxidase Inhibitors" @default.
- W2152912193 doi "https://doi.org/10.2174/0929867023371229" @default.
- W2152912193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11860355" @default.
- W2152912193 hasPublicationYear "2002" @default.
- W2152912193 type Work @default.
- W2152912193 sameAs 2152912193 @default.
- W2152912193 citedByCount "309" @default.
- W2152912193 countsByYear W21529121932012 @default.
- W2152912193 countsByYear W21529121932013 @default.
- W2152912193 countsByYear W21529121932014 @default.
- W2152912193 countsByYear W21529121932015 @default.
- W2152912193 countsByYear W21529121932016 @default.
- W2152912193 countsByYear W21529121932017 @default.
- W2152912193 countsByYear W21529121932018 @default.
- W2152912193 countsByYear W21529121932019 @default.
- W2152912193 countsByYear W21529121932020 @default.
- W2152912193 countsByYear W21529121932021 @default.
- W2152912193 countsByYear W21529121932022 @default.
- W2152912193 countsByYear W21529121932023 @default.
- W2152912193 crossrefType "journal-article" @default.
- W2152912193 hasAuthorship W2152912193A5003956314 @default.
- W2152912193 hasAuthorship W2152912193A5031955097 @default.
- W2152912193 hasAuthorship W2152912193A5068000809 @default.
- W2152912193 hasConcept C126322002 @default.
- W2152912193 hasConcept C151400659 @default.
- W2152912193 hasConcept C181199279 @default.
- W2152912193 hasConcept C185592680 @default.
- W2152912193 hasConcept C2776943133 @default.
- W2152912193 hasConcept C2777477808 @default.
- W2152912193 hasConcept C2777820942 @default.
- W2152912193 hasConcept C2778102346 @default.
- W2152912193 hasConcept C2778979269 @default.
- W2152912193 hasConcept C2779721657 @default.
- W2152912193 hasConcept C2779840689 @default.
- W2152912193 hasConcept C2779881121 @default.
- W2152912193 hasConcept C2780261098 @default.
- W2152912193 hasConcept C2780795997 @default.
- W2152912193 hasConcept C2780932893 @default.
- W2152912193 hasConcept C48349386 @default.
- W2152912193 hasConcept C55493867 @default.
- W2152912193 hasConcept C71924100 @default.
- W2152912193 hasConceptScore W2152912193C126322002 @default.
- W2152912193 hasConceptScore W2152912193C151400659 @default.
- W2152912193 hasConceptScore W2152912193C181199279 @default.
- W2152912193 hasConceptScore W2152912193C185592680 @default.
- W2152912193 hasConceptScore W2152912193C2776943133 @default.
- W2152912193 hasConceptScore W2152912193C2777477808 @default.
- W2152912193 hasConceptScore W2152912193C2777820942 @default.
- W2152912193 hasConceptScore W2152912193C2778102346 @default.
- W2152912193 hasConceptScore W2152912193C2778979269 @default.
- W2152912193 hasConceptScore W2152912193C2779721657 @default.
- W2152912193 hasConceptScore W2152912193C2779840689 @default.
- W2152912193 hasConceptScore W2152912193C2779881121 @default.
- W2152912193 hasConceptScore W2152912193C2780261098 @default.
- W2152912193 hasConceptScore W2152912193C2780795997 @default.
- W2152912193 hasConceptScore W2152912193C2780932893 @default.
- W2152912193 hasConceptScore W2152912193C48349386 @default.
- W2152912193 hasConceptScore W2152912193C55493867 @default.
- W2152912193 hasConceptScore W2152912193C71924100 @default.
- W2152912193 hasIssue "2" @default.
- W2152912193 hasLocation W21529121931 @default.
- W2152912193 hasLocation W21529121932 @default.
- W2152912193 hasOpenAccess W2152912193 @default.
- W2152912193 hasPrimaryLocation W21529121931 @default.
- W2152912193 hasRelatedWork W125501084 @default.
- W2152912193 hasRelatedWork W1996296076 @default.
- W2152912193 hasRelatedWork W2005245742 @default.
- W2152912193 hasRelatedWork W2016604128 @default.
- W2152912193 hasRelatedWork W2060957265 @default.
- W2152912193 hasRelatedWork W2151146447 @default.
- W2152912193 hasRelatedWork W2306225133 @default.
- W2152912193 hasRelatedWork W2317201136 @default.
- W2152912193 hasRelatedWork W2793103574 @default.
- W2152912193 hasRelatedWork W2951015564 @default.
- W2152912193 hasVolume "9" @default.
- W2152912193 isParatext "false" @default.
- W2152912193 isRetracted "false" @default.
- W2152912193 magId "2152912193" @default.
- W2152912193 workType "article" @default.