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- W2152912347 abstract "Sir,Danazol, an inhibitor of pituitary gonadotropin with weak androgenic effects, is currently used in the treatment of endometriosis, hereditary angio‐oedema, systemic lupus erythematosus, and idiopathic thrombocytopenic purpura (ITP). Its hepatological side‐effects have been well documented. These include reversible elevations of serum aminotransferase values,1 cholestatic hepatitis,2 hepatic peliosis3 and hepatocellular adenomas.4 Only a few cases of danazol‐associated hepatocellular carcinoma (HCC) have been described.5–,7 We report a new case.A 37‐year‐old female with ITP refractory to corticotherapy, intravenous immunoglobulins, vincristine and splenectomy, was treated with 600 mg danazol daily in March 1995. Danazol induced a dramatic clinical and biological response, settling thrombocytes counts at 40×109 …" @default.
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- W2152912347 date "2003-04-01" @default.
- W2152912347 modified "2023-10-02" @default.
- W2152912347 title "Danazol‐induced hepatocellular carcinoma" @default.
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- W2152912347 doi "https://doi.org/10.1093/qjmed/hcg050" @default.
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