Matches in SemOpenAlex for { <https://semopenalex.org/work/W2152912682> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2152912682 abstract "Objectives To improve the safety of the preparation and its availability in ophthalmology, a ready-to-use cefuroxime syringe prepared under aseptic conditions according to good manufacturing practice was developed by the hospital pharmacy. Methods The chemical stability of cefuroxime solution at 10 mg/mL in 0.9% sodium chloride in syringes (0.5 mL) was achieved at −18°C by a capillary electrophoresis method. Syringes of the last acceptable time were then stored at 4°C and the study was continued for one additional month. The pH was measured throughout the study and the presence of particle matter was controlled. Sterility testing was performed to test the integrity of the syringes. Results An optimal period of 4 months at −18°C was defined for storage of syringes of cefuroxime without significant loss in potency and an acceptable rate (4%) of degradation products. After thawing and storage at 4°C, degradation products progressively increased. As these derivatives can represent up to 10% of cefuroxime in terms of peak area after 1 month, it is recommended that the syringes are used within 1 h after thawing. The pH did not change appreciably during the study and the sterility testing results were negative. Moreover, in all cases the syringes fulfilled all the European Pharmacopoeia criteria with regard to non-visible particles. Conclusions The availability of cefuroxime for use in ophthalmology is improved as ready-to-use syringes can be stored in the ward freezer and administered immediately after thawing." @default.
- W2152912682 created "2016-06-24" @default.
- W2152912682 creator A5001683266 @default.
- W2152912682 creator A5051283897 @default.
- W2152912682 creator A5062812912 @default.
- W2152912682 date "2013-07-24" @default.
- W2152912682 modified "2023-10-02" @default.
- W2152912682 title "Development of ready-to-use cefuroxime syringes for use in ophthalmology" @default.
- W2152912682 cites W132045794 @default.
- W2152912682 cites W1989561359 @default.
- W2152912682 cites W2032100351 @default.
- W2152912682 cites W2044195512 @default.
- W2152912682 cites W2075069758 @default.
- W2152912682 cites W2078038328 @default.
- W2152912682 cites W2116035831 @default.
- W2152912682 cites W2128460295 @default.
- W2152912682 cites W2155478747 @default.
- W2152912682 doi "https://doi.org/10.1136/ejhpharm-2013-000307" @default.
- W2152912682 hasPublicationYear "2013" @default.
- W2152912682 type Work @default.
- W2152912682 sameAs 2152912682 @default.
- W2152912682 citedByCount "4" @default.
- W2152912682 countsByYear W21529126822012 @default.
- W2152912682 countsByYear W21529126822015 @default.
- W2152912682 countsByYear W21529126822021 @default.
- W2152912682 countsByYear W21529126822023 @default.
- W2152912682 crossrefType "journal-article" @default.
- W2152912682 hasAuthorship W2152912682A5001683266 @default.
- W2152912682 hasAuthorship W2152912682A5051283897 @default.
- W2152912682 hasAuthorship W2152912682A5062812912 @default.
- W2152912682 hasConcept C104863432 @default.
- W2152912682 hasConcept C118552586 @default.
- W2152912682 hasConcept C141071460 @default.
- W2152912682 hasConcept C159110408 @default.
- W2152912682 hasConcept C181268634 @default.
- W2152912682 hasConcept C185592680 @default.
- W2152912682 hasConcept C196762363 @default.
- W2152912682 hasConcept C2777514703 @default.
- W2152912682 hasConcept C2778571141 @default.
- W2152912682 hasConcept C43617362 @default.
- W2152912682 hasConcept C501593827 @default.
- W2152912682 hasConcept C55493867 @default.
- W2152912682 hasConcept C71924100 @default.
- W2152912682 hasConcept C72092618 @default.
- W2152912682 hasConceptScore W2152912682C104863432 @default.
- W2152912682 hasConceptScore W2152912682C118552586 @default.
- W2152912682 hasConceptScore W2152912682C141071460 @default.
- W2152912682 hasConceptScore W2152912682C159110408 @default.
- W2152912682 hasConceptScore W2152912682C181268634 @default.
- W2152912682 hasConceptScore W2152912682C185592680 @default.
- W2152912682 hasConceptScore W2152912682C196762363 @default.
- W2152912682 hasConceptScore W2152912682C2777514703 @default.
- W2152912682 hasConceptScore W2152912682C2778571141 @default.
- W2152912682 hasConceptScore W2152912682C43617362 @default.
- W2152912682 hasConceptScore W2152912682C501593827 @default.
- W2152912682 hasConceptScore W2152912682C55493867 @default.
- W2152912682 hasConceptScore W2152912682C71924100 @default.
- W2152912682 hasConceptScore W2152912682C72092618 @default.
- W2152912682 hasLocation W21529126821 @default.
- W2152912682 hasOpenAccess W2152912682 @default.
- W2152912682 hasPrimaryLocation W21529126821 @default.
- W2152912682 hasRelatedWork W121228155 @default.
- W2152912682 hasRelatedWork W1867184850 @default.
- W2152912682 hasRelatedWork W1955044212 @default.
- W2152912682 hasRelatedWork W2011568851 @default.
- W2152912682 hasRelatedWork W2060442383 @default.
- W2152912682 hasRelatedWork W2063845425 @default.
- W2152912682 hasRelatedWork W2074487270 @default.
- W2152912682 hasRelatedWork W2099525976 @default.
- W2152912682 hasRelatedWork W2149847571 @default.
- W2152912682 hasRelatedWork W2157703367 @default.
- W2152912682 hasRelatedWork W2170942096 @default.
- W2152912682 hasRelatedWork W2179418560 @default.
- W2152912682 hasRelatedWork W2344828796 @default.
- W2152912682 hasRelatedWork W2393222081 @default.
- W2152912682 hasRelatedWork W2394042106 @default.
- W2152912682 hasRelatedWork W2399059351 @default.
- W2152912682 hasRelatedWork W2410014732 @default.
- W2152912682 hasRelatedWork W2913312241 @default.
- W2152912682 hasRelatedWork W1438871144 @default.
- W2152912682 hasRelatedWork W2183264063 @default.
- W2152912682 isParatext "false" @default.
- W2152912682 isRetracted "false" @default.
- W2152912682 magId "2152912682" @default.
- W2152912682 workType "article" @default.