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• W2152912783 endingPage "R1508" @default.
• W2152912783 startingPage "R1499" @default.
• W2152912783 abstract "Ondansetron, a selective serotonin-type 3 (5-HT 3 ) receptor antagonist, was used to test the hypothesis that duodenal infusion of isosmotic solutions of Polycose or its hydrolytic product glucose suppressed intake through 5-HT 3 receptors. Polycose suppressed sucrose intake across both concentrations infused (132 mM, 7.6 ± 0.6 ml; 263 mM, 2.3 ± 0.5 ml), compared with intake under control conditions (12.6 ± 0.3 ml, P <0.001). Pretreatment with 1.0 mg/kg ondansetron attenuated reduction of sucrose intake induced only by the highest concentration of Polycose (4.6 ± 0.8 ml, P = 0.004). Dose-response testing revealed that suppression of food intake by 263 mM Polycose was equally attenuated by ondansetron administered at 1.0, 2.0, and 5.0 mg/kg but not when given at 0.125, 0.25, and 0.5 mg/kg. Acarbose, an α-glucosidase inhibitor, attenuated Polycose-induced suppression of food intake, and pretreatment with 1.0 mg/kg ondansetron had no further effect. Suppression of intake after 990 mM glucose but not mannitol infusion was attenuated by pretreatment with 1.0 mg/kg ondansetron. The competitive SGLT 1 inhibitor, phloridzin, had no effect on 60-min 990 mM glucose-induced suppression of intake or the ability of ondansetron to attenuate this suppression of intake. Conversely, glucose-induced suppression of intake was attenuated by phloridzin at earlier time points and further attenuated when rats were pretreated with 1.0 mg/kg ondansetron. Ondansetron administration alone had no effect on intake at any dose tested. We conclude that 5-HT 3 receptors participate in the inhibition of food intake by intraduodenal infusion of carbohydrate solutions through a posthydrolytic, preabsorptive mechanism." @default.
• W2152912783 created "2016-06-24" @default.
• W2152912783 creator A5032105543 @default.
• W2152912783 creator A5047642898 @default.
• W2152912783 creator A5060613483 @default.
• W2152912783 date "2005-06-01" @default.
• W2152912783 modified "2023-09-28" @default.
• W2152912783 title "Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake" @default.
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• W2152912783 doi "https://doi.org/10.1152/ajpregu.00745.2004" @default.
• W2152912783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15718390" @default.
• W2152912783 hasPublicationYear "2005" @default.
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