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• W2152918507 abstract "The chimeric nature of the transplanted liver was first shown in our long-surviving human recipients of orthotopic hepatic allografts in 1969.1 When liver grafts were obtained from cadaveric donors of the opposite sex, karyotyping studies showed that hepatocytes and endothelium of major blood vessels retained their donor specificity, whereas the entire macrophage system, including Kuppfer cells, was replaced with recipient cells.2 Where donor cells that had left the liver had gone was unknown, but their continued presence was confirmed by the acquisition and maintenance in recipient blood of new donor-specific immunoglobulin (Gm) types1,3 and red-blood-cell alloantibodies, if donors with ABO non-identity were used.4 Davies et al5 attributed the secretion of new soluble HLA class I antigens of donor type to transplanted hepatocytes. However, these HLA molecules come from bone-marrow-derived macrophages and/or dendritic cells,6 and probably have the same origin from migrated donor cells as the additional Gm types and red-cell antibodies." @default.
• W2152918507 created "2016-06-24" @default.
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• W2152918507 date "1992-06-01" @default.
• W2152918507 modified "2023-10-11" @default.
• W2152918507 title "Cell migration, chimerism, and graft acceptance" @default.
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• W2152918507 doi "https://doi.org/10.1016/0140-6736(92)91840-5" @default.
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