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• W2152923668 abstract "Clinical trials are usually designed to meet registration requirements in developed countries, and do not always address key concerns for use in developing countries. Four late-stage investigational new drugs - rilpivirine, etravirine, raltegravir and maraviroc - show potential to improve antiretroviral therapy. However, a number of issues could limit their use in developing countries, including dose selection, treatment strategy, combination with other drugs, use in specific populations and reliance on expensive tests. Key research questions relevant for developing countries need to be answered early in the drug development process to ensure maximum benefit for the majority." @default.
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• W2152923668 date "2008-07-01" @default.
• W2152923668 modified "2023-09-23" @default.
• W2152923668 title "How developing world concerns need to be part of drug development plans: a case study of four emerging antiretrovirals" @default.
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• W2152923668 doi "https://doi.org/10.1016/j.drudis.2008.04.009" @default.
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