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• W2152987932 abstract "Pseudoknots play critical roles in packing the active structure of various functional RNAs. The importance of the P3–P7 pseudoknot in refolding of group I intron ribozymes has been recently appreciated, while little is known about the pseudoknot function in co-transcriptional folding. Here we used the Candida group I intron as a model to address the question. We show that co-transcriptional folding of the active self-splicing intron is twice as fast as refolding. The P3–P7 pseudoknot folds slowly during co-transcriptional folding at a rate constant similar to the folding of the active ribozyme, and folding of both P3–P7 and P1–P10 pseudoknots are inhibited by antisense oligonucleotides. We conclude that when RNA folding is coupled with transcription, formation of pseudoknot structures dominates the productive folding pathway and serves as a rate-limiting step in producing the self-splicing competent Candida intron." @default.
• W2152987932 created "2016-06-24" @default.
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• W2152987932 date "2009-08-26" @default.
• W2152987932 modified "2023-09-27" @default.
• W2152987932 title "Slow formation of a pseudoknot structure is rate limiting in the productive co-transcriptional folding of the self-splicing <i>Candida</i> intron" @default.
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• W2152987932 doi "https://doi.org/10.1261/rna.1638609" @default.
• W2152987932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2764484" @default.
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