FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153002415> ?p ?o ?g. }

• W2153002415 endingPage "3490" @default.
• W2153002415 startingPage "3482" @default.
• W2153002415 abstract "In order to improve the absorption of nanoparticles in the brain following nasal administration, a novel protocol to conjugate biorecognitive ligands—lectins to the surface of poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanoparticles was established in the study. Wheat germ agglutinin (WGA), specifically binding to N-acetyl-d-glucosamine and sialic acid, both of which were abundantly observed in the nasal cavity, was selected as a model lectin. The WGA-conjugated nanoparticles were prepared by incorporating maleimide in the PLA–PEG molecular and taking advantage of its thiol group binding reactivity to conjugate with 2-iminothialane thiolated WGA. Coupling of WGA with the PEG–PLA nanoparticles was confirmed by the existence of gold-labeled WGA-NP under TEM. The retention of biorecognitive activity of WGA after the covalent coupling procedure was confirmed by haemagglutination test. The resulting nanoparticles presented negligible nasal ciliatoxicity and the brain uptake of a fluorescent marker—coumarin carried by WGA functionized nanoparticles was about 2 folds in different brain tissues compared with that of coumarin incorporated in the unmodified ones. Thus, the technique offered a novel effective noninvasive system for brain drug delivery, especially for brain protein and gene delivery." @default.
• W2153002415 created "2016-06-24" @default.
• W2153002415 creator A5000363531 @default.
• W2153002415 creator A5004136136 @default.
• W2153002415 creator A5033648917 @default.
• W2153002415 creator A5035830977 @default.
• W2153002415 creator A5074124696 @default.
• W2153002415 creator A5086664284 @default.
• W2153002415 creator A5088958812 @default.
• W2153002415 date "2006-06-01" @default.
• W2153002415 modified "2023-10-11" @default.
• W2153002415 title "Lectin-conjugated PEG–PLA nanoparticles: Preparation and brain delivery after intranasal administration" @default.
• W2153002415 cites W1494872149 @default.
• W2153002415 cites W1506654534 @default.
• W2153002415 cites W1508895967 @default.
• W2153002415 cites W1557482465 @default.
• W2153002415 cites W1664986234 @default.
• W2153002415 cites W1767611922 @default.
• W2153002415 cites W1965478395 @default.
• W2153002415 cites W1969953999 @default.
• W2153002415 cites W1986129921 @default.
• W2153002415 cites W2002434100 @default.
• W2153002415 cites W2003116578 @default.
• W2153002415 cites W2006370393 @default.
• W2153002415 cites W2009805582 @default.
• W2153002415 cites W2020302862 @default.
• W2153002415 cites W2021913844 @default.
• W2153002415 cites W2054306978 @default.
• W2153002415 cites W2063276424 @default.
• W2153002415 cites W2074667182 @default.
• W2153002415 cites W2079369954 @default.
• W2153002415 cites W2083266859 @default.
• W2153002415 cites W2090402863 @default.
• W2153002415 cites W2091322268 @default.
• W2153002415 cites W2134349585 @default.
• W2153002415 cites W2157183580 @default.
• W2153002415 cites W2163771644 @default.
• W2153002415 cites W2175440008 @default.
• W2153002415 cites W2399183422 @default.
• W2153002415 doi "https://doi.org/10.1016/j.biomaterials.2006.01.038" @default.
• W2153002415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16510178" @default.
• W2153002415 hasPublicationYear "2006" @default.
• W2153002415 type Work @default.
• W2153002415 sameAs 2153002415 @default.
• W2153002415 citedByCount "255" @default.
• W2153002415 countsByYear W21530024152012 @default.
• W2153002415 countsByYear W21530024152013 @default.
• W2153002415 countsByYear W21530024152014 @default.
• W2153002415 countsByYear W21530024152015 @default.
• W2153002415 countsByYear W21530024152016 @default.
• W2153002415 countsByYear W21530024152017 @default.
• W2153002415 countsByYear W21530024152018 @default.
• W2153002415 countsByYear W21530024152019 @default.
• W2153002415 countsByYear W21530024152020 @default.
• W2153002415 countsByYear W21530024152021 @default.
• W2153002415 countsByYear W21530024152022 @default.
• W2153002415 countsByYear W21530024152023 @default.
• W2153002415 crossrefType "journal-article" @default.
• W2153002415 hasAuthorship W2153002415A5000363531 @default.
• W2153002415 hasAuthorship W2153002415A5004136136 @default.
• W2153002415 hasAuthorship W2153002415A5033648917 @default.
• W2153002415 hasAuthorship W2153002415A5035830977 @default.
• W2153002415 hasAuthorship W2153002415A5074124696 @default.
• W2153002415 hasAuthorship W2153002415A5086664284 @default.
• W2153002415 hasAuthorship W2153002415A5088958812 @default.
• W2153002415 hasConcept C10138342 @default.
• W2153002415 hasConcept C112613896 @default.
• W2153002415 hasConcept C12554922 @default.
• W2153002415 hasConcept C134306372 @default.
• W2153002415 hasConcept C162324750 @default.
• W2153002415 hasConcept C171250308 @default.
• W2153002415 hasConcept C178790620 @default.
• W2153002415 hasConcept C185592680 @default.
• W2153002415 hasConcept C192562407 @default.
• W2153002415 hasConcept C197336794 @default.
• W2153002415 hasConcept C2777516009 @default.
• W2153002415 hasConcept C2779820397 @default.
• W2153002415 hasConcept C2780115458 @default.
• W2153002415 hasConcept C2780175098 @default.
• W2153002415 hasConcept C2780758401 @default.
• W2153002415 hasConcept C33923547 @default.
• W2153002415 hasConcept C521977710 @default.
• W2153002415 hasConcept C54400483 @default.
• W2153002415 hasConcept C55493867 @default.
• W2153002415 hasConcept C85663871 @default.
• W2153002415 hasConcept C86803240 @default.
• W2153002415 hasConcept C98274493 @default.
• W2153002415 hasConceptScore W2153002415C10138342 @default.
• W2153002415 hasConceptScore W2153002415C112613896 @default.
• W2153002415 hasConceptScore W2153002415C12554922 @default.
• W2153002415 hasConceptScore W2153002415C134306372 @default.
• W2153002415 hasConceptScore W2153002415C162324750 @default.
• W2153002415 hasConceptScore W2153002415C171250308 @default.
• W2153002415 hasConceptScore W2153002415C178790620 @default.
• W2153002415 hasConceptScore W2153002415C185592680 @default.
• W2153002415 hasConceptScore W2153002415C192562407 @default.
• W2153002415 hasConceptScore W2153002415C197336794 @default.
• W2153002415 hasConceptScore W2153002415C2777516009 @default.

• next