FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153003314> ?p ?o ?g. }

• W2153003314 endingPage "9" @default.
• W2153003314 startingPage "2973" @default.
• W2153003314 abstract "Lung cancer remains the number one cause of cancer-related deaths in the United States. To reduce the mortality associated with this disease, individuals at risk must be identified prior to the development of lung cancer, and effective prevention strategies must be developed. One such strategy is to use retinoids like N-(4-hydroxyphenyl)retinamide (4-HPR), which has been found to possess chemopreventive activities in preclinical studies. In this study, 139 smokers were registered and 82 were randomized onto a double-blinded, placebo-controlled chemoprevention trial of 4-HPR administered p.o. (200 mg once daily). Of these, 70 participants were eligible for response evaluation. Biopsies were obtained at six predetermined sites in the bronchial tree from participants before and at the completion of 6 months of treatment. 4-HPR treatment had no measurable effect on histopathology (squamous metaplasia and dysplasia) in the bronchial epithelium of current smokers. 4-HPR was detected (104.5+/-64.0 ng/ml, mean +/- SD) in the serum of participants, supporting its potential bioavailability. Serum retinol levels decreased markedly (44% of placebo-treated patients) as a consequence of 4-HPR treatment. Notably, the mRNA level of retinoic acid receptor beta, which is typically increased by retinoid treatment, did not change in the bronchial epithelium of 4-HPR-treated participants. Clonal populations of bronchial epithelial cells were detected by analysis of loss of heterozygosity at putative tumor suppressor loci on chromosomes 3p, 9p, and 17p, and these changes were not altered by 4-HPR treatment. In conclusion, at this dose and schedule, 4-HPR was not effective in reversing squamous metaplasia, dysplasia, or genetic and phenotypic abnormalities in the bronchial epithelium of smokers." @default.
• W2153003314 created "2016-06-24" @default.
• W2153003314 creator A5010218106 @default.
• W2153003314 creator A5020414083 @default.
• W2153003314 creator A5023135321 @default.
• W2153003314 creator A5030797960 @default.
• W2153003314 creator A5039814984 @default.
• W2153003314 creator A5045457153 @default.
• W2153003314 creator A5053021930 @default.
• W2153003314 creator A5059550832 @default.
• W2153003314 creator A5063003854 @default.
• W2153003314 creator A5065839430 @default.
• W2153003314 creator A5066684019 @default.
• W2153003314 creator A5069190968 @default.
• W2153003314 creator A5075931431 @default.
• W2153003314 creator A5083051785 @default.
• W2153003314 creator A5085188591 @default.
• W2153003314 creator A5091374629 @default.
• W2153003314 date "2000-08-01" @default.
• W2153003314 modified "2023-10-13" @default.
• W2153003314 title "N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium." @default.
• W2153003314 cites W1493790738 @default.
• W2153003314 cites W1513980229 @default.
• W2153003314 cites W1514651365 @default.
• W2153003314 cites W1525444530 @default.
• W2153003314 cites W1545071010 @default.
• W2153003314 cites W1559888577 @default.
• W2153003314 cites W174661090 @default.
• W2153003314 cites W1806469554 @default.
• W2153003314 cites W1825062505 @default.
• W2153003314 cites W1838012124 @default.
• W2153003314 cites W1867619861 @default.
• W2153003314 cites W1912278559 @default.
• W2153003314 cites W1925078242 @default.
• W2153003314 cites W1966165057 @default.
• W2153003314 cites W1978579555 @default.
• W2153003314 cites W1980231023 @default.
• W2153003314 cites W1994331461 @default.
• W2153003314 cites W2022731225 @default.
• W2153003314 cites W2028170381 @default.
• W2153003314 cites W2047576691 @default.
• W2153003314 cites W2062465964 @default.
• W2153003314 cites W2070059475 @default.
• W2153003314 cites W2070684162 @default.
• W2153003314 cites W2098860085 @default.
• W2153003314 cites W2100579560 @default.
• W2153003314 cites W2102211380 @default.
• W2153003314 cites W2109568316 @default.
• W2153003314 cites W2112773069 @default.
• W2153003314 cites W2132696570 @default.
• W2153003314 cites W2134532087 @default.
• W2153003314 cites W2138422909 @default.
• W2153003314 cites W2149858443 @default.
• W2153003314 cites W2154015002 @default.
• W2153003314 cites W2176891727 @default.
• W2153003314 cites W2235593194 @default.
• W2153003314 cites W2313655951 @default.
• W2153003314 cites W2316276336 @default.
• W2153003314 cites W2317242858 @default.
• W2153003314 cites W2332357435 @default.
• W2153003314 cites W2394650275 @default.
• W2153003314 cites W2419382111 @default.
• W2153003314 cites W2460191037 @default.
• W2153003314 cites W566534948 @default.
• W2153003314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10955773" @default.
• W2153003314 hasPublicationYear "2000" @default.
• W2153003314 type Work @default.
• W2153003314 sameAs 2153003314 @default.
• W2153003314 citedByCount "31" @default.
• W2153003314 countsByYear W21530033142012 @default.
• W2153003314 countsByYear W21530033142014 @default.
• W2153003314 countsByYear W21530033142015 @default.
• W2153003314 countsByYear W21530033142016 @default.
• W2153003314 countsByYear W21530033142017 @default.
• W2153003314 crossrefType "journal-article" @default.
• W2153003314 hasAuthorship W2153003314A5010218106 @default.
• W2153003314 hasAuthorship W2153003314A5020414083 @default.
• W2153003314 hasAuthorship W2153003314A5023135321 @default.
• W2153003314 hasAuthorship W2153003314A5030797960 @default.
• W2153003314 hasAuthorship W2153003314A5039814984 @default.
• W2153003314 hasAuthorship W2153003314A5045457153 @default.
• W2153003314 hasAuthorship W2153003314A5053021930 @default.
• W2153003314 hasAuthorship W2153003314A5059550832 @default.
• W2153003314 hasAuthorship W2153003314A5063003854 @default.
• W2153003314 hasAuthorship W2153003314A5065839430 @default.
• W2153003314 hasAuthorship W2153003314A5066684019 @default.
• W2153003314 hasAuthorship W2153003314A5069190968 @default.
• W2153003314 hasAuthorship W2153003314A5075931431 @default.
• W2153003314 hasAuthorship W2153003314A5083051785 @default.
• W2153003314 hasAuthorship W2153003314A5085188591 @default.
• W2153003314 hasAuthorship W2153003314A5091374629 @default.
• W2153003314 hasConcept C104317684 @default.
• W2153003314 hasConcept C121608353 @default.
• W2153003314 hasConcept C126322002 @default.
• W2153003314 hasConcept C142724271 @default.
• W2153003314 hasConcept C143998085 @default.
• W2153003314 hasConcept C204787440 @default.
• W2153003314 hasConcept C27081682 @default.

• next