Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153010223> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2153010223 endingPage "459" @default.
- W2153010223 startingPage "458" @default.
- W2153010223 abstract "<h3>Abstract</h3> The gastrointestinal (GI) tract is inhabited by a complex microbial community, which contributes to its homeostasis. Disrupted microbiome can cause GI-related diseases, including inflammatory bowel disease, therefore identifying host-microbe interactions is crucial for better understanding gut health. Bacterial extracellular vesicles (BEVs), released into the gut lumen, can cross the mucus layer and access underlying immune cells. To study cross-kingdom communication between BEVs and host, we focused on the influence of BEVs, generated by <i>Bacteroides thetaiotaomicron</i> (VPI-5482), on host immune cells. Using single-cell RNA sequencing data and host-microbe protein-protein interaction networks, we examined the potential effect of BEVs on dendritic cells, macrophages and monocytes with particular focus on the Toll-like receptor (TLR) pathway. We identified biological processes affected in each immune cell type, and also cell-type specific processes (e.g myeloid cell differentiation). The TLR pathway analysis highlighted that BEV targets differ among cells and even between the same cells in healthy versus disease (ulcerative colitis) conditions. Our <i>in silico</i> findings were validated in BEV-monocyte co-cultures demonstrating the requirement for TLR4 in BEV-elicited NF-κ B activation. This study demonstrates that both cell-type and health condition influence BEV-host communication. The results and the pipeline can facilitate BEV-based therapy development for the treatment of IBD." @default.
- W2153010223 created "2016-06-24" @default.
- W2153010223 creator A5059503566 @default.
- W2153010223 date "1887-08-27" @default.
- W2153010223 modified "2023-09-25" @default.
- W2153010223 title "The Treatment of Laryngeal Phthisis" @default.
- W2153010223 doi "https://doi.org/10.1136/bmj.2.1391.458" @default.
- W2153010223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2535042" @default.
- W2153010223 hasPublicationYear "1887" @default.
- W2153010223 type Work @default.
- W2153010223 sameAs 2153010223 @default.
- W2153010223 citedByCount "0" @default.
- W2153010223 crossrefType "journal-article" @default.
- W2153010223 hasAuthorship W2153010223A5059503566 @default.
- W2153010223 hasConcept C136449434 @default.
- W2153010223 hasConcept C143121216 @default.
- W2153010223 hasConcept C1491633281 @default.
- W2153010223 hasConcept C189014844 @default.
- W2153010223 hasConcept C203014093 @default.
- W2153010223 hasConcept C2778513237 @default.
- W2153010223 hasConcept C2779282312 @default.
- W2153010223 hasConcept C2781236682 @default.
- W2153010223 hasConcept C502942594 @default.
- W2153010223 hasConcept C54355233 @default.
- W2153010223 hasConcept C60644358 @default.
- W2153010223 hasConcept C71924100 @default.
- W2153010223 hasConcept C86803240 @default.
- W2153010223 hasConcept C8891405 @default.
- W2153010223 hasConceptScore W2153010223C136449434 @default.
- W2153010223 hasConceptScore W2153010223C143121216 @default.
- W2153010223 hasConceptScore W2153010223C1491633281 @default.
- W2153010223 hasConceptScore W2153010223C189014844 @default.
- W2153010223 hasConceptScore W2153010223C203014093 @default.
- W2153010223 hasConceptScore W2153010223C2778513237 @default.
- W2153010223 hasConceptScore W2153010223C2779282312 @default.
- W2153010223 hasConceptScore W2153010223C2781236682 @default.
- W2153010223 hasConceptScore W2153010223C502942594 @default.
- W2153010223 hasConceptScore W2153010223C54355233 @default.
- W2153010223 hasConceptScore W2153010223C60644358 @default.
- W2153010223 hasConceptScore W2153010223C71924100 @default.
- W2153010223 hasConceptScore W2153010223C86803240 @default.
- W2153010223 hasConceptScore W2153010223C8891405 @default.
- W2153010223 hasIssue "1391" @default.
- W2153010223 hasLocation W21530102231 @default.
- W2153010223 hasOpenAccess W2153010223 @default.
- W2153010223 hasPrimaryLocation W21530102231 @default.
- W2153010223 hasRelatedWork W1556307916 @default.
- W2153010223 hasRelatedWork W1914689199 @default.
- W2153010223 hasRelatedWork W1981462882 @default.
- W2153010223 hasRelatedWork W2085108411 @default.
- W2153010223 hasRelatedWork W2103515427 @default.
- W2153010223 hasRelatedWork W2103675344 @default.
- W2153010223 hasRelatedWork W2141330728 @default.
- W2153010223 hasRelatedWork W2178262593 @default.
- W2153010223 hasRelatedWork W2902358729 @default.
- W2153010223 hasRelatedWork W4281774408 @default.
- W2153010223 hasVolume "2" @default.
- W2153010223 isParatext "false" @default.
- W2153010223 isRetracted "false" @default.
- W2153010223 magId "2153010223" @default.
- W2153010223 workType "article" @default.