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• W2153012417 abstract "Dosage compensation is a specialized gene regulatory mechanism which equalizes X-linked gene expression between sexes. In Caenorhabditis elegans, dosage compensation is achieved by the activity of the dosage compensation complex (DCC). The DCC localizes to both X chromosomes in hermaphrodites to downregulate gene expression by half. The DCC contains a subcomplex (condensin IDC) similar to the evolutionarily conserved condensin complexes which play fundamental roles in chromosome dynamics during mitosis and meiosis. Therefore, mechanisms related to mitotic chromosome condensation have been long hypothesized to mediate dosage compensation. However experimental evidence was lacking. Using 3D FISH microscopy to measure the volumes of X and chromosome I territories and to measure distances between individual loci, we show that hermaphrodite worms deficient in DCC proteins have enlarged interphase X chromosomes when compared to wild type. By contrast, chromosome I is unaffected. Interestingly, hermaphrodite worms depleted of condensin I or II show no phenotype. Therefore X chromosome compaction is specific to condensin IDC. In addition, we show that SET-1, SET-4, and SIR-2.1, histone modifiers whose activity is regulated by the DCC, need to be present for the compaction of the X chromosome territory. These results support the idea that condensin IDC, and the histone modifications regulated by the DCC, mediate interphase X chromosome compaction. Our results link condensin-mediated chromosome compaction, an activity connected to mitotic chromosome condensation, to chromosome-wide repression of gene expression in interphase." @default.
• W2153012417 created "2016-06-24" @default.
• W2153012417 creator A5011827207 @default.
• W2153012417 creator A5035651173 @default.
• W2153012417 creator A5087458767 @default.
• W2153012417 date "2014-10-27" @default.
• W2153012417 modified "2023-10-17" @default.
• W2153012417 title "The C. elegans dosage compensation complex mediates interphase X chromosome compaction" @default.
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• W2153012417 doi "https://doi.org/10.1186/1756-8935-7-31" @default.
• W2153012417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4232692" @default.
• W2153012417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25400696" @default.
• W2153012417 hasPublicationYear "2014" @default.
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