Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153021575> ?p ?o ?g. }
- W2153021575 abstract "Though used for over a century, structural bone allografts suffer from a high rate of mechanical failure due to limited graft revitalization even after extended periods in vivo. Novel strategies that aim to improve graft incorporation are lacking but necessary to improve the long-term clinical outcome of patients receiving bone allografts. The current study evaluated the effect of low-intensity pulsed ultrasound (LIPUS), a potent exogenous biophysical stimulus used clinically to accelerate the course of fresh fracture healing, and longitudinal allograft perforations (LAP) as non-invasive therapies to improve revitalization of intercalary allografts in a sheep model. Fifteen skeletally-mature ewes were assigned to five experimental groups based on allograft type and treatment: +CTL, -CTL, LIPUS, LAP, LIPUS+LAP. The +CTL animals (n = 3) received a tibial ostectomy with immediate replacement of the resected autologous graft. The -CTL group (n = 3) received fresh frozen ovine tibial allografts. The +CTL and -CTL groups did not receive LAP or LIPUS treatments. The LIPUS treatment group (n = 3), following grafting with fresh frozen ovine tibial allografts, received ultrasound stimulation for 20 minutes/day, 5 days/week, for the duration of the healing period. The LAP treatment group (n = 3) received fresh frozen ovine allografts with 500 μm longitudinal perforations that extended 10 mm into the graft. The LIPUS+LAP treatment group (n = 3) received both LIPUS and LAP interventions. All animals were humanely euthanized four months following graft transplantation for biomechanical and histological analysis. After four months of healing, daily LIPUS stimulation of the host-allograft junctions, alone or in combination with LAP, resulted in 30% increases in reconstruction stiffness, paralleled by significant increases (p < 0.001) in callus maturity and periosteal bridging across the host/allograft interfaces. Longitudinal perforations extending 10 mm into the proximal and distal endplates filled to varying degrees with new appositional bone and significantly accelerated revitalization of the allografts compared to controls. The current study has demonstrated in a large animal model the potential of both LIPUS and LAP therapy to improve the degree of allograft incorporation. LAP may provide an option for increasing porosity, and thus potential in vivo osseous apposition and revitalization, without adversely affecting the structural integrity of the graft." @default.
- W2153021575 created "2016-06-24" @default.
- W2153021575 creator A5013680696 @default.
- W2153021575 creator A5028696292 @default.
- W2153021575 creator A5044528475 @default.
- W2153021575 creator A5076354561 @default.
- W2153021575 date "2008-05-27" @default.
- W2153021575 modified "2023-09-25" @default.
- W2153021575 title "Effects of low intensity pulsed ultrasound with and without increased cortical porosity on structural bone allograft incorporation" @default.
- W2153021575 cites W1950612832 @default.
- W2153021575 cites W1968899197 @default.
- W2153021575 cites W1971059737 @default.
- W2153021575 cites W1976975614 @default.
- W2153021575 cites W1982413446 @default.
- W2153021575 cites W1982496800 @default.
- W2153021575 cites W1983527126 @default.
- W2153021575 cites W1985659604 @default.
- W2153021575 cites W1998976978 @default.
- W2153021575 cites W2005268482 @default.
- W2153021575 cites W2008341797 @default.
- W2153021575 cites W2013316218 @default.
- W2153021575 cites W2023254683 @default.
- W2153021575 cites W2034403497 @default.
- W2153021575 cites W2053858083 @default.
- W2153021575 cites W2062055981 @default.
- W2153021575 cites W2066511467 @default.
- W2153021575 cites W2070796291 @default.
- W2153021575 cites W2074187946 @default.
- W2153021575 cites W2085821199 @default.
- W2153021575 cites W2086197605 @default.
- W2153021575 cites W2087378917 @default.
- W2153021575 cites W2087392545 @default.
- W2153021575 cites W2125758927 @default.
- W2153021575 cites W2126171001 @default.
- W2153021575 cites W2129331493 @default.
- W2153021575 cites W2134028135 @default.
- W2153021575 cites W2147471673 @default.
- W2153021575 cites W2180722336 @default.
- W2153021575 cites W2215356021 @default.
- W2153021575 cites W2249364713 @default.
- W2153021575 cites W4238854496 @default.
- W2153021575 cites W6230995 @default.
- W2153021575 doi "https://doi.org/10.1186/1749-799x-3-20" @default.
- W2153021575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2414658" @default.
- W2153021575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18505579" @default.
- W2153021575 hasPublicationYear "2008" @default.
- W2153021575 type Work @default.
- W2153021575 sameAs 2153021575 @default.
- W2153021575 citedByCount "10" @default.
- W2153021575 countsByYear W21530215752013 @default.
- W2153021575 countsByYear W21530215752014 @default.
- W2153021575 countsByYear W21530215752018 @default.
- W2153021575 countsByYear W21530215752019 @default.
- W2153021575 countsByYear W21530215752021 @default.
- W2153021575 crossrefType "journal-article" @default.
- W2153021575 hasAuthorship W2153021575A5013680696 @default.
- W2153021575 hasAuthorship W2153021575A5028696292 @default.
- W2153021575 hasAuthorship W2153021575A5044528475 @default.
- W2153021575 hasAuthorship W2153021575A5076354561 @default.
- W2153021575 hasBestOaLocation W21530215751 @default.
- W2153021575 hasConcept C126838900 @default.
- W2153021575 hasConcept C141071460 @default.
- W2153021575 hasConcept C143753070 @default.
- W2153021575 hasConcept C147969180 @default.
- W2153021575 hasConcept C167672396 @default.
- W2153021575 hasConcept C203014093 @default.
- W2153021575 hasConcept C2777236700 @default.
- W2153021575 hasConcept C2778550726 @default.
- W2153021575 hasConcept C2779727089 @default.
- W2153021575 hasConcept C2911091166 @default.
- W2153021575 hasConcept C71924100 @default.
- W2153021575 hasConcept C8337478 @default.
- W2153021575 hasConcept C8891405 @default.
- W2153021575 hasConceptScore W2153021575C126838900 @default.
- W2153021575 hasConceptScore W2153021575C141071460 @default.
- W2153021575 hasConceptScore W2153021575C143753070 @default.
- W2153021575 hasConceptScore W2153021575C147969180 @default.
- W2153021575 hasConceptScore W2153021575C167672396 @default.
- W2153021575 hasConceptScore W2153021575C203014093 @default.
- W2153021575 hasConceptScore W2153021575C2777236700 @default.
- W2153021575 hasConceptScore W2153021575C2778550726 @default.
- W2153021575 hasConceptScore W2153021575C2779727089 @default.
- W2153021575 hasConceptScore W2153021575C2911091166 @default.
- W2153021575 hasConceptScore W2153021575C71924100 @default.
- W2153021575 hasConceptScore W2153021575C8337478 @default.
- W2153021575 hasConceptScore W2153021575C8891405 @default.
- W2153021575 hasIssue "1" @default.
- W2153021575 hasLocation W21530215751 @default.
- W2153021575 hasLocation W21530215752 @default.
- W2153021575 hasLocation W21530215753 @default.
- W2153021575 hasLocation W21530215754 @default.
- W2153021575 hasLocation W21530215755 @default.
- W2153021575 hasOpenAccess W2153021575 @default.
- W2153021575 hasPrimaryLocation W21530215751 @default.
- W2153021575 hasRelatedWork W1898418644 @default.
- W2153021575 hasRelatedWork W1981120621 @default.
- W2153021575 hasRelatedWork W2030037686 @default.
- W2153021575 hasRelatedWork W2038775719 @default.
- W2153021575 hasRelatedWork W2043757691 @default.
- W2153021575 hasRelatedWork W2079108491 @default.