Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153046378> ?p ?o ?g. }
- W2153046378 endingPage "588" @default.
- W2153046378 startingPage "580" @default.
- W2153046378 abstract "Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Two ACAT genes exist in mammals. We report here the genomic organization of human ACAT-2 gene and analysis of its promoter activity in various cell lines. The human ACAT-2 gene spans over 18 kb and contains 15 exons. Three transcription start sites and one poly(A) site are identified by the 5′/3′-RACE. In addition, the human ACAT-2 gene is linked to the insulin-like growth factor binding protein 6 (IGFBP-6) gene in a head-to-tail manner with a small intergenic region of about 1.2 kb. The 5′-flanking region of human ACAT-2 gene contains many potential cis-acting elements for multiple transcriptional regulatory factors but lacks TATA and CCAAT boxes. Using promoter-luciferase reporter assays, we demonstrate the transcriptional activity of ACAT-2 gene promoter is high in Caco-2 cells, especially after these cells become postconfluent and behave as intestinal enterocytes." @default.
- W2153046378 created "2016-06-24" @default.
- W2153046378 creator A5003666988 @default.
- W2153046378 creator A5008808671 @default.
- W2153046378 creator A5047179498 @default.
- W2153046378 creator A5049759564 @default.
- W2153046378 creator A5060898939 @default.
- W2153046378 creator A5074348362 @default.
- W2153046378 creator A5075842751 @default.
- W2153046378 date "2001-03-01" @default.
- W2153046378 modified "2023-09-26" @default.
- W2153046378 title "Organization of Human ACAT-2 Gene and Its Cell-Type-Specific Promoter Activity" @default.
- W2153046378 cites W1493781700 @default.
- W2153046378 cites W1508733793 @default.
- W2153046378 cites W1528470195 @default.
- W2153046378 cites W1579635094 @default.
- W2153046378 cites W1582816865 @default.
- W2153046378 cites W1675154176 @default.
- W2153046378 cites W1722478811 @default.
- W2153046378 cites W1762207328 @default.
- W2153046378 cites W1823018609 @default.
- W2153046378 cites W1832765217 @default.
- W2153046378 cites W1924905604 @default.
- W2153046378 cites W1975235816 @default.
- W2153046378 cites W1982863094 @default.
- W2153046378 cites W1983130452 @default.
- W2153046378 cites W1987183604 @default.
- W2153046378 cites W1987666378 @default.
- W2153046378 cites W1996953344 @default.
- W2153046378 cites W2000798721 @default.
- W2153046378 cites W2004944257 @default.
- W2153046378 cites W2006616124 @default.
- W2153046378 cites W2020981258 @default.
- W2153046378 cites W2021243296 @default.
- W2153046378 cites W2021350807 @default.
- W2153046378 cites W2036702421 @default.
- W2153046378 cites W2039999119 @default.
- W2153046378 cites W2043817812 @default.
- W2153046378 cites W2044296969 @default.
- W2153046378 cites W2065014938 @default.
- W2153046378 cites W2068345120 @default.
- W2153046378 cites W2070017875 @default.
- W2153046378 cites W2072585523 @default.
- W2153046378 cites W2080754482 @default.
- W2153046378 cites W2094905879 @default.
- W2153046378 cites W2098137011 @default.
- W2153046378 cites W2115149771 @default.
- W2153046378 cites W2124241844 @default.
- W2153046378 cites W2124760389 @default.
- W2153046378 cites W2149699485 @default.
- W2153046378 cites W2151217611 @default.
- W2153046378 cites W2151602225 @default.
- W2153046378 cites W2158964347 @default.
- W2153046378 cites W2188790645 @default.
- W2153046378 cites W2256245985 @default.
- W2153046378 cites W2324013291 @default.
- W2153046378 cites W4246101295 @default.
- W2153046378 cites W4248775888 @default.
- W2153046378 doi "https://doi.org/10.1006/bbrc.2001.4612" @default.
- W2153046378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11401500" @default.
- W2153046378 hasPublicationYear "2001" @default.
- W2153046378 type Work @default.
- W2153046378 sameAs 2153046378 @default.
- W2153046378 citedByCount "25" @default.
- W2153046378 countsByYear W21530463782012 @default.
- W2153046378 countsByYear W21530463782013 @default.
- W2153046378 countsByYear W21530463782014 @default.
- W2153046378 countsByYear W21530463782016 @default.
- W2153046378 crossrefType "journal-article" @default.
- W2153046378 hasAuthorship W2153046378A5003666988 @default.
- W2153046378 hasAuthorship W2153046378A5008808671 @default.
- W2153046378 hasAuthorship W2153046378A5047179498 @default.
- W2153046378 hasAuthorship W2153046378A5049759564 @default.
- W2153046378 hasAuthorship W2153046378A5060898939 @default.
- W2153046378 hasAuthorship W2153046378A5074348362 @default.
- W2153046378 hasAuthorship W2153046378A5075842751 @default.
- W2153046378 hasConcept C101762097 @default.
- W2153046378 hasConcept C104317684 @default.
- W2153046378 hasConcept C138885662 @default.
- W2153046378 hasConcept C150194340 @default.
- W2153046378 hasConcept C153911025 @default.
- W2153046378 hasConcept C161733203 @default.
- W2153046378 hasConcept C165864922 @default.
- W2153046378 hasConcept C179926584 @default.
- W2153046378 hasConcept C27153228 @default.
- W2153046378 hasConcept C2778163477 @default.
- W2153046378 hasConcept C2780072125 @default.
- W2153046378 hasConcept C36823959 @default.
- W2153046378 hasConcept C37002583 @default.
- W2153046378 hasConcept C41895202 @default.
- W2153046378 hasConcept C54355233 @default.
- W2153046378 hasConcept C55493867 @default.
- W2153046378 hasConcept C86339819 @default.
- W2153046378 hasConcept C86803240 @default.
- W2153046378 hasConceptScore W2153046378C101762097 @default.
- W2153046378 hasConceptScore W2153046378C104317684 @default.
- W2153046378 hasConceptScore W2153046378C138885662 @default.
- W2153046378 hasConceptScore W2153046378C150194340 @default.