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• W2153057126 abstract "To assess the relationship between serum cytokines and cytomegalovirus (CMV) reactivation, 75 allogeneic bone marrow transplant patients underwent weekly measurements of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α, CMV blood cultures, and antigenemia tests. Of the patients, 44 (58.7%) developed CMV infection, and 19 (25.3%) developed clinical CMV disease. The mean maximum levels of all three cytokines were significantly increased in patients with CMV infection compared with levels in those without. Maximum levels of IL-6 were significantly higher in patients with active CMV disease than in those who did not develop CMV disease (281.2 ± 85.5 vs. 95.7 ± 15.0 pg/mL; P = .034). Levels of IL-8 and TNF-α were also elevated in patients who developed active disease. In a multivariate logistic regression model, IL-6 levels were independently associated with CMV disease (odds ratio = 1.70 per 100-pg/mL increase in IL-6; P = .009). Cytokines may play an important role in the pathogenesis of CMV after bone marrow transplantation and may be a useful predictor for CMV." @default.
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• W2153057126 date "1999-02-01" @default.
• W2153057126 modified "2023-09-24" @default.
• W2153057126 title "Elevated Serum Cytokines Are Associated with Cytomegalovirus Infection and Disease in Bone Marrow Transplant Recipients" @default.
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• W2153057126 doi "https://doi.org/10.1086/314602" @default.
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