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- W2153060595 abstract "After several decades of vaccination against hepatitis B virus in newborns, infants, adolescents, and adults, the question remains whether a booster dose is ever needed. Long-term protection is most commonly measured through 4 methods: the anamnestic response after administration of a booster dose, infection rate in vaccinated populations, in vitro B and T cell activity testing, and seroepidemiological studies. Long-term protection is present despite a decrease in anti-hepatitis B surface antibodies over time. The exact mechanism of long-term protection, however, is not yet fully understood. There is no need for boosters in immunologically potent persons as long as a full course was adequately administered that respected the recommended timelines, as evidenced by studies conducted up to 20 years after the original immunization course. However, a booster dose should be planned for immunocompromised patients, based on serological monitoring." @default.
- W2153060595 created "2016-06-24" @default.
- W2153060595 creator A5058655705 @default.
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- W2153060595 date "2011-06-07" @default.
- W2153060595 modified "2023-10-03" @default.
- W2153060595 title "Hepatitis B and the Need for a Booster Dose" @default.
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- W2153060595 doi "https://doi.org/10.1093/cid/cir270" @default.
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