Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153070852> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2153070852 endingPage "602" @default.
- W2153070852 startingPage "593" @default.
- W2153070852 abstract "1. The influence of the free radical of diaziquone on inhibition of cell growth in vitro was studied using P388 murine leukaemia cells and a mixture of AZQH2 + AZQ. This mixture generates the AZQ free radical by the disproportionation-comproportionation reaction AZQH2 + AZQ⇌2AZQH.2. Reduced AZQ (AZQH2) was produced electrochemically under anaerobic conditions. This colourless solution was added anaerobically to a solution of AZQ at a 9 : 1 ratio of AZQH2 to AZQ. The free radical (AZQH) generated was detected by electron spin resonance (ESR) and amounted to about 7% of the concn of AZQH2 + AZQ. The AZQ free radical was stable enough to treat cells in culture.3. Aerobic suspensions of P388 murine leukaemia cells treated with AZQH experienced a surge of free radicals lasting approx. 30 min at concn near 10 times that of the AZQ free radicals generated by P388 cells.4. Cell growth inhibition indicates that the concentration of AZQ required to arrest the growth of P388 cells by 50% (IC50) is twice that of the AZQ free radical generating mixture. The mechanism of action of AZQ probably does not exclusively involve AZQ free radicals, but they appear to play an important role." @default.
- W2153070852 created "2016-06-24" @default.
- W2153070852 creator A5020169937 @default.
- W2153070852 creator A5025257865 @default.
- W2153070852 creator A5055826757 @default.
- W2153070852 date "1988-01-01" @default.
- W2153070852 modified "2023-09-25" @default.
- W2153070852 title "The influence of diaziquone free radicals on the in vitro activity of diaziquone" @default.
- W2153070852 cites W1971296064 @default.
- W2153070852 cites W2000604632 @default.
- W2153070852 cites W2004248446 @default.
- W2153070852 cites W2021236154 @default.
- W2153070852 cites W2028851019 @default.
- W2153070852 cites W2144329663 @default.
- W2153070852 cites W2160043291 @default.
- W2153070852 cites W4211258263 @default.
- W2153070852 cites W4234762889 @default.
- W2153070852 doi "https://doi.org/10.3109/00498258809041696" @default.
- W2153070852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2840783" @default.
- W2153070852 hasPublicationYear "1988" @default.
- W2153070852 type Work @default.
- W2153070852 sameAs 2153070852 @default.
- W2153070852 citedByCount "9" @default.
- W2153070852 crossrefType "journal-article" @default.
- W2153070852 hasAuthorship W2153070852A5020169937 @default.
- W2153070852 hasAuthorship W2153070852A5025257865 @default.
- W2153070852 hasAuthorship W2153070852A5055826757 @default.
- W2153070852 hasConcept C139066938 @default.
- W2153070852 hasConcept C147789679 @default.
- W2153070852 hasConcept C161790260 @default.
- W2153070852 hasConcept C164397293 @default.
- W2153070852 hasConcept C17365422 @default.
- W2153070852 hasConcept C17525397 @default.
- W2153070852 hasConcept C185592680 @default.
- W2153070852 hasConcept C52859227 @default.
- W2153070852 hasConcept C55493867 @default.
- W2153070852 hasConceptScore W2153070852C139066938 @default.
- W2153070852 hasConceptScore W2153070852C147789679 @default.
- W2153070852 hasConceptScore W2153070852C161790260 @default.
- W2153070852 hasConceptScore W2153070852C164397293 @default.
- W2153070852 hasConceptScore W2153070852C17365422 @default.
- W2153070852 hasConceptScore W2153070852C17525397 @default.
- W2153070852 hasConceptScore W2153070852C185592680 @default.
- W2153070852 hasConceptScore W2153070852C52859227 @default.
- W2153070852 hasConceptScore W2153070852C55493867 @default.
- W2153070852 hasIssue "5" @default.
- W2153070852 hasLocation W21530708521 @default.
- W2153070852 hasLocation W21530708522 @default.
- W2153070852 hasOpenAccess W2153070852 @default.
- W2153070852 hasPrimaryLocation W21530708521 @default.
- W2153070852 hasRelatedWork W1972224716 @default.
- W2153070852 hasRelatedWork W2004344232 @default.
- W2153070852 hasRelatedWork W2009241587 @default.
- W2153070852 hasRelatedWork W2033426405 @default.
- W2153070852 hasRelatedWork W2054108765 @default.
- W2153070852 hasRelatedWork W2118517483 @default.
- W2153070852 hasRelatedWork W2324765957 @default.
- W2153070852 hasRelatedWork W2334641655 @default.
- W2153070852 hasRelatedWork W2950975823 @default.
- W2153070852 hasRelatedWork W2951220323 @default.
- W2153070852 hasVolume "18" @default.
- W2153070852 isParatext "false" @default.
- W2153070852 isRetracted "false" @default.
- W2153070852 magId "2153070852" @default.
- W2153070852 workType "article" @default.