FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153087598> ?p ?o ?g. }

• W2153087598 endingPage "502" @default.
• W2153087598 startingPage "497" @default.
• W2153087598 abstract "BACKGROUND: Diabetes is a major risk factor for coronary heart disease in women and event rates increase substantially after the menopause. Observational studies have suggested that estrogens may provide cardioprotection by regulating endothelial nitric oxide synthase. METHODS: In order to examine the effect of hormone replacement therapy (HRT) on endothelium-dependent and -independent vascular relaxation in post-menopausal women with type 2 diabetes, an open study was conducted in which gluteal biopsies were collected from 17 women before and after 6 months of transdermal 17β-estradiol (80 μg twice weekly) in combination with oral norethisterone (1 mg daily). Small arteries (<550 μm) were dissected from fat and mounted on a wire myograph for assessment of relaxation in response to acetylcholine (ACh), bradykinin (BK) and sodium nitroprusside (SNP). RESULTS: Maximal relaxation responses to ACh, BK and SNP in women with diabetes and non-diabetic control subjects were 52 ± 8 versus 96 ± 2% (P < 0.05), 76 ± 7 versus 97 ± 1%, (P < 0.05) and 91 ± 2 versus 98 ± 1% (P < 0.05) respectively. After 6 months of HRT, maximal relaxation responses to ACh, BK and SNP in women with diabetes (compared with pre-HRT) were: 88 ± 4 (P < 0.05), 93 ± 3 (P < 0.05) and 98 ± 1% (P < 0.05) respectively. At baseline and after HRT, EC50 (concentration required to obtain 50% of maximum response) data exhibited similar changes. CONCLUSIONS: HRT had potentially beneficial effects on vascular relaxation. Data were consistent with improvements in endothelial function, vascular smooth muscle function, or both. Controlled studies are required to confirm and extend these findings." @default.
• W2153087598 created "2016-06-24" @default.
• W2153087598 creator A5007118282 @default.
• W2153087598 creator A5011738463 @default.
• W2153087598 creator A5019200508 @default.
• W2153087598 creator A5034927677 @default.
• W2153087598 creator A5056323976 @default.
• W2153087598 creator A5063541240 @default.
• W2153087598 creator A5077595764 @default.
• W2153087598 date "2002-02-01" @default.
• W2153087598 modified "2023-10-18" @default.
• W2153087598 title "Hormone replacement therapy can augment vascular relaxation in post-menopausal women with type 2 diabetes" @default.
• W2153087598 cites W1484535674 @default.
• W2153087598 cites W1512772699 @default.
• W2153087598 cites W1604542334 @default.
• W2153087598 cites W1797673917 @default.
• W2153087598 cites W1821918060 @default.
• W2153087598 cites W1913777752 @default.
• W2153087598 cites W1965287127 @default.
• W2153087598 cites W1977655005 @default.
• W2153087598 cites W1980270769 @default.
• W2153087598 cites W1987876724 @default.
• W2153087598 cites W1991403690 @default.
• W2153087598 cites W1993387626 @default.
• W2153087598 cites W1998000672 @default.
• W2153087598 cites W2012458916 @default.
• W2153087598 cites W2015756205 @default.
• W2153087598 cites W2018143170 @default.
• W2153087598 cites W2021662691 @default.
• W2153087598 cites W2022750242 @default.
• W2153087598 cites W2027501985 @default.
• W2153087598 cites W2036947502 @default.
• W2153087598 cites W2055870525 @default.
• W2153087598 cites W2057009504 @default.
• W2153087598 cites W2059537042 @default.
• W2153087598 cites W2060339082 @default.
• W2153087598 cites W2064461781 @default.
• W2153087598 cites W2064525346 @default.
• W2153087598 cites W2067317689 @default.
• W2153087598 cites W2067454866 @default.
• W2153087598 cites W2067696654 @default.
• W2153087598 cites W2068729533 @default.
• W2153087598 cites W2071073097 @default.
• W2153087598 cites W2075078490 @default.
• W2153087598 cites W2086056327 @default.
• W2153087598 cites W2087426603 @default.
• W2153087598 cites W2098587915 @default.
• W2153087598 cites W2101651570 @default.
• W2153087598 cites W2102319363 @default.
• W2153087598 cites W2104852764 @default.
• W2153087598 cites W2113264115 @default.
• W2153087598 cites W2114544525 @default.
• W2153087598 cites W2137570167 @default.
• W2153087598 cites W2140385110 @default.
• W2153087598 cites W2140503446 @default.
• W2153087598 cites W2141651784 @default.
• W2153087598 cites W2163376944 @default.
• W2153087598 cites W2316376271 @default.
• W2153087598 cites W2338100645 @default.
• W2153087598 cites W2406837376 @default.
• W2153087598 cites W2615633554 @default.
• W2153087598 cites W3157860773 @default.
• W2153087598 cites W1992034930 @default.
• W2153087598 doi "https://doi.org/10.1093/humrep/17.2.497" @default.
• W2153087598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11821303" @default.
• W2153087598 hasPublicationYear "2002" @default.
• W2153087598 type Work @default.
• W2153087598 sameAs 2153087598 @default.
• W2153087598 citedByCount "21" @default.
• W2153087598 countsByYear W21530875982012 @default.
• W2153087598 countsByYear W21530875982013 @default.
• W2153087598 countsByYear W21530875982014 @default.
• W2153087598 crossrefType "journal-article" @default.
• W2153087598 hasAuthorship W2153087598A5007118282 @default.
• W2153087598 hasAuthorship W2153087598A5011738463 @default.
• W2153087598 hasAuthorship W2153087598A5019200508 @default.
• W2153087598 hasAuthorship W2153087598A5034927677 @default.
• W2153087598 hasAuthorship W2153087598A5056323976 @default.
• W2153087598 hasAuthorship W2153087598A5063541240 @default.
• W2153087598 hasAuthorship W2153087598A5077595764 @default.
• W2153087598 hasBestOaLocation W21530875981 @default.
• W2153087598 hasConcept C126322002 @default.
• W2153087598 hasConcept C134018914 @default.
• W2153087598 hasConcept C2776992346 @default.
• W2153087598 hasConcept C2777180221 @default.
• W2153087598 hasConcept C2778562196 @default.
• W2153087598 hasConcept C2779279991 @default.
• W2153087598 hasConcept C2779610285 @default.
• W2153087598 hasConcept C2779941686 @default.
• W2153087598 hasConcept C2780159708 @default.
• W2153087598 hasConcept C2780972559 @default.
• W2153087598 hasConcept C519581460 @default.
• W2153087598 hasConcept C555293320 @default.
• W2153087598 hasConcept C71924100 @default.
• W2153087598 hasConceptScore W2153087598C126322002 @default.
• W2153087598 hasConceptScore W2153087598C134018914 @default.
• W2153087598 hasConceptScore W2153087598C2776992346 @default.
• W2153087598 hasConceptScore W2153087598C2777180221 @default.

• next