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- W2153092127 abstract "The threonine phosphatase eyes absent (EYA) has been identified as a novel regulator of innate immune responses to cytosolicnucleic acids and undigested DNA from apoptotic cells. EYA regulates responses of yet unidentified DNA sensors and enhancesinterferon-b and CXCL10 transcription.The effects of cell death on the outcome ofimmune responses are diverse and rangefrom silent or tolerogenic effects in thecaseofplainapoptosistostrongactivationin the case of necrosis or inflammatory celldeath in the course of infection (Greenetal.,2009).Variouscomponentsreleasedfrom dying cells can act as activators ofinnateimmunecellsandcanberecognizedas damage- or danger-associated molecu-lar patterns (DAMPs). Arguably, the bestcharacterized DAMP that activates innateimmune cells is high mobility group box-1protein, released from necrotic cells(Green et al., 2009). Chromosomal DNAalso represents a potent DAMP andimmune reactions to DNA have beenassociated with autoimmune diseasessuch as lupus erythematosus or rheuma-toid arthritis (Green et al., 2009). Thesensor mechanisms are still poorlydefined, although several receptor pro-teins that are able to sense double-stranded (ds)-DNA and activate innateimmune cells have been identified(Ranjan et al., 2009). During apoptosis,chromosomal DNA is fragmented andrapidly degraded primarily throughcaspase-activated DNase (CAD) to avoidinnate immune activation. ChromosomalDNA that escapes degradation by CAD isefficiently digested in phagocytes byDNase II. Nagata and colleagues hadpreviously shown that defective DNAdegradation caused inflammation andautoimmunity in mice lacking DNase II(Okabe et al., 2009). DNA accumulated inlysosomes of DNase II" @default.
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- W2153092127 date "2009-01-01" @default.
- W2153092127 modified "2023-09-26" @default.
- W2153092127 title "Research Highlight Innate Immune Cells Cast an Eye on DNA" @default.
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