Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153095927> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2153095927 endingPage "6" @default.
- W2153095927 startingPage "740" @default.
- W2153095927 abstract "Previous investigations demonstrated gallium arsenide (GaAs) to be an immunosuppressive agent that alters the function of all cell types involved in the generation of a primary antibody response. In those studies, GaAs was administered as a particulate compound that remained in the lung at least 14 days after exposure. The extended presence of the particulate in the lung may induce a stress response that leads to the release of endogenous corticosteroids. In addition, some of the observed immunomodulatory effects of GaAs were similar to immunological alterations reported to be induced by corticosteroids. The present studies were designed to determine whether suppression of the immunoglobulin (Ig) M antibody-forming calls (AFC) response by GaAs was a result of a GaAs-induced increase in serum corticosterone. GaAs (50-200 mg/kg) significantly decreased the weights of both the thymus and spleen and the cellularity of the spleen. In addition, there was a GaAs-induced decrease in the CD4+/CD8+ thymocyte subpopulations and a concomitant increase in CD4+ and CD8+ cells. Within the spleen, there were no alterations in the percentages of CD4, CD8 or Ig-positive cells. However, when expressed as an absolute cell number, there was a 50% decrease in the numbers of CD4+ and CD8+ cells in the spleen. GaAs also dose-dependently suppressed (50-75%) the IgM AFC response. The GaAs-induced changes in cell populations and immune organ weights were correlated with an increase (6- to 10-fold) in serum corticosterone levels. The treatment of mice with the glucocorticoid antagonist mifepristone (also called RU 486) blocked the observed alterations in splenic and thymic cell populations induced by GaAs.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2153095927 created "2016-06-24" @default.
- W2153095927 creator A5003072947 @default.
- W2153095927 creator A5016202701 @default.
- W2153095927 creator A5046702660 @default.
- W2153095927 creator A5084527662 @default.
- W2153095927 date "1994-02-01" @default.
- W2153095927 modified "2023-09-26" @default.
- W2153095927 title "Gallium arsenide-induced increase in serum corticosterone is not responsible for suppression of the IgM antibody response." @default.
- W2153095927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7509391" @default.
- W2153095927 hasPublicationYear "1994" @default.
- W2153095927 type Work @default.
- W2153095927 sameAs 2153095927 @default.
- W2153095927 citedByCount "6" @default.
- W2153095927 countsByYear W21530959272014 @default.
- W2153095927 crossrefType "journal-article" @default.
- W2153095927 hasAuthorship W2153095927A5003072947 @default.
- W2153095927 hasAuthorship W2153095927A5016202701 @default.
- W2153095927 hasAuthorship W2153095927A5046702660 @default.
- W2153095927 hasAuthorship W2153095927A5084527662 @default.
- W2153095927 hasConcept C126322002 @default.
- W2153095927 hasConcept C134018914 @default.
- W2153095927 hasConcept C159654299 @default.
- W2153095927 hasConcept C16613235 @default.
- W2153095927 hasConcept C167672396 @default.
- W2153095927 hasConcept C185592680 @default.
- W2153095927 hasConcept C203014093 @default.
- W2153095927 hasConcept C2776090121 @default.
- W2153095927 hasConcept C2778826759 @default.
- W2153095927 hasConcept C2779234561 @default.
- W2153095927 hasConcept C2780004078 @default.
- W2153095927 hasConcept C2780352252 @default.
- W2153095927 hasConcept C2780841215 @default.
- W2153095927 hasConcept C2780931953 @default.
- W2153095927 hasConcept C54355233 @default.
- W2153095927 hasConcept C59493245 @default.
- W2153095927 hasConcept C71315377 @default.
- W2153095927 hasConcept C71924100 @default.
- W2153095927 hasConcept C86803240 @default.
- W2153095927 hasConcept C8891405 @default.
- W2153095927 hasConceptScore W2153095927C126322002 @default.
- W2153095927 hasConceptScore W2153095927C134018914 @default.
- W2153095927 hasConceptScore W2153095927C159654299 @default.
- W2153095927 hasConceptScore W2153095927C16613235 @default.
- W2153095927 hasConceptScore W2153095927C167672396 @default.
- W2153095927 hasConceptScore W2153095927C185592680 @default.
- W2153095927 hasConceptScore W2153095927C203014093 @default.
- W2153095927 hasConceptScore W2153095927C2776090121 @default.
- W2153095927 hasConceptScore W2153095927C2778826759 @default.
- W2153095927 hasConceptScore W2153095927C2779234561 @default.
- W2153095927 hasConceptScore W2153095927C2780004078 @default.
- W2153095927 hasConceptScore W2153095927C2780352252 @default.
- W2153095927 hasConceptScore W2153095927C2780841215 @default.
- W2153095927 hasConceptScore W2153095927C2780931953 @default.
- W2153095927 hasConceptScore W2153095927C54355233 @default.
- W2153095927 hasConceptScore W2153095927C59493245 @default.
- W2153095927 hasConceptScore W2153095927C71315377 @default.
- W2153095927 hasConceptScore W2153095927C71924100 @default.
- W2153095927 hasConceptScore W2153095927C86803240 @default.
- W2153095927 hasConceptScore W2153095927C8891405 @default.
- W2153095927 hasIssue "2" @default.
- W2153095927 hasLocation W21530959271 @default.
- W2153095927 hasOpenAccess W2153095927 @default.
- W2153095927 hasPrimaryLocation W21530959271 @default.
- W2153095927 hasRelatedWork W1992533206 @default.
- W2153095927 hasRelatedWork W2000954890 @default.
- W2153095927 hasRelatedWork W2034277681 @default.
- W2153095927 hasRelatedWork W2036237097 @default.
- W2153095927 hasRelatedWork W2048505384 @default.
- W2153095927 hasRelatedWork W2063533487 @default.
- W2153095927 hasRelatedWork W2068129327 @default.
- W2153095927 hasRelatedWork W2213857395 @default.
- W2153095927 hasRelatedWork W2355436147 @default.
- W2153095927 hasRelatedWork W2461219896 @default.
- W2153095927 hasVolume "268" @default.
- W2153095927 isParatext "false" @default.
- W2153095927 isRetracted "false" @default.
- W2153095927 magId "2153095927" @default.
- W2153095927 workType "article" @default.