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• W2153099903 endingPage "4" @default.
• W2153099903 startingPage "4" @default.
• W2153099903 abstract "Intraoperative reductions in serum fentanyl concentrations during transdermal fentanyl (TDF) administration in dogs with induced moderate hypothermia have been reported. The impact of these reductions on any anesthetic sparing effect has not been evaluated in dogs. The objective of this investigation was to determine whether the minimum alveolar concentration (MAC) of isoflurane is altered in the presence of transdermal fentanyl in normothermic and hypothermic dogs. Six mature, healthy, mixed breed dogs were anesthetized on four separate occasions, and received each of the four following treatments in random order: (i) Sham patch-normothermia (C-NORM), (ii) Sham patch-hypothermia (C-HYPO), (iii) TDF-normothermia (F-NORM), 4. TDF-hypothermia (F-HYPO). Twenty-four hours prior to induction of anesthesia, a sham or a 75 μg hour−1 fentanyl patch was applied. Following induction with isoflurane, the dogs were intubated and mechanically ventilated. Animals in the hypothermia group were cooled to 34.5 °C; normothermia was maintained in the other group. MAC determinations were performed using a current (50 cycles second−1, 6.5 milliseconds duration, 40 volts) applied to needle electrodes placed 4 cm apart in the buccal mucosa of the lower jaw of the dog. The MAC (±SD) for C-NORM, C-HYPO, F-NORM and F-HYPO was 1.196 ± 0.167, 0.855 ± 0.183, 0.763 ± 0.097, and 0.830 ± 0.172, respectively. MAC for C-NORM was significantly higher than the other groups. There was a significant difference between C-NORM and F-NORM. There was no significant difference between C-HYPO, F-NORM, and F-HYPO. TDF in hypothermic dogs appears to provide no greater anesthetic sparing effect than that associated with moderate hypothermia. These findings suggest that reductions in serum fentanyl concentrations seen with moderate hypothermia are the result of a decrease of drug uptake rather than a shift of the active drug to the biophase." @default.
• W2153099903 created "2016-06-24" @default.
• W2153099903 creator A5027058699 @default.
• W2153099903 creator A5031066318 @default.
• W2153099903 creator A5045845233 @default.
• W2153099903 date "2005-07-01" @default.
• W2153099903 modified "2023-09-27" @default.
• W2153099903 title "The influence of transdermally administered fentanyl on isoflurane requirements in normothermic and hypothermic dogs" @default.
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