Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153101275> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2153101275 endingPage "97" @default.
- W2153101275 startingPage "93" @default.
- W2153101275 abstract "Researchers have noted that mammographic screening has a reduced effect on breast cancer mortality in women in their forties compared to older women. Explanations for this include poorer sensitivity in younger women due to denser breast tissue, as well as more rapid tumor progression, giving a shorter mean sojourn time (the average duration of the preclinical screen-detectable period). To test these hypotheses, we developed a series of Markov-chain models to estimate tumor progression rates and sensitivity. Parameters were estimated using tumor data from the Swedish two-county trial of mammographic screening for breast cancer. The mean sojourn time was shorter in women aged 40-49 compared to women aged 50-59 and 60-69 (2.44, 3.70, and 4.17 years, respectively). Sensitivity was lower in the 40-49 age group compared to the two older groups (83%, 100%, and 100%, respectively). Thus, both rapid progression and poorer sensitivity are associated with the 40-49 age group. We also modeled tumor size, node status, and malignancy grade together with subsequent breast cancer mortality and found that, to achieve a reduction in mortality commensurate with that in women over 50, the interscreening interval for women in their forties should be less than two years. We conclude that Markov models and the use of tumor size, node status, and malignancy grade as surrogates for mortality can be useful in design and analysis of future studies of breast cancer screening." @default.
- W2153101275 created "2016-06-24" @default.
- W2153101275 creator A5012645942 @default.
- W2153101275 creator A5033978146 @default.
- W2153101275 creator A5035627161 @default.
- W2153101275 creator A5042074298 @default.
- W2153101275 creator A5060965552 @default.
- W2153101275 date "1997-01-01" @default.
- W2153101275 modified "2023-09-25" @default.
- W2153101275 title "Markov Models of Breast Tumor Progression: Some Age-Specific Results" @default.
- W2153101275 cites W2012045214 @default.
- W2153101275 cites W2030622127 @default.
- W2153101275 cites W2086889792 @default.
- W2153101275 cites W2087434646 @default.
- W2153101275 cites W2094707334 @default.
- W2153101275 cites W2135002375 @default.
- W2153101275 cites W2264964449 @default.
- W2153101275 cites W2312350966 @default.
- W2153101275 cites W2331522917 @default.
- W2153101275 cites W2464723405 @default.
- W2153101275 cites W4244827167 @default.
- W2153101275 doi "https://doi.org/10.1093/jncimono/1997.22.93" @default.
- W2153101275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9709283" @default.
- W2153101275 hasPublicationYear "1997" @default.
- W2153101275 type Work @default.
- W2153101275 sameAs 2153101275 @default.
- W2153101275 citedByCount "99" @default.
- W2153101275 countsByYear W21531012752012 @default.
- W2153101275 countsByYear W21531012752013 @default.
- W2153101275 countsByYear W21531012752014 @default.
- W2153101275 countsByYear W21531012752015 @default.
- W2153101275 countsByYear W21531012752016 @default.
- W2153101275 countsByYear W21531012752017 @default.
- W2153101275 countsByYear W21531012752018 @default.
- W2153101275 countsByYear W21531012752019 @default.
- W2153101275 countsByYear W21531012752020 @default.
- W2153101275 countsByYear W21531012752021 @default.
- W2153101275 countsByYear W21531012752022 @default.
- W2153101275 countsByYear W21531012752023 @default.
- W2153101275 crossrefType "journal-article" @default.
- W2153101275 hasAuthorship W2153101275A5012645942 @default.
- W2153101275 hasAuthorship W2153101275A5033978146 @default.
- W2153101275 hasAuthorship W2153101275A5035627161 @default.
- W2153101275 hasAuthorship W2153101275A5042074298 @default.
- W2153101275 hasAuthorship W2153101275A5060965552 @default.
- W2153101275 hasBestOaLocation W21531012751 @default.
- W2153101275 hasConcept C121608353 @default.
- W2153101275 hasConcept C126322002 @default.
- W2153101275 hasConcept C143998085 @default.
- W2153101275 hasConcept C2779399171 @default.
- W2153101275 hasConcept C2780472235 @default.
- W2153101275 hasConcept C29456083 @default.
- W2153101275 hasConcept C530470458 @default.
- W2153101275 hasConcept C71924100 @default.
- W2153101275 hasConceptScore W2153101275C121608353 @default.
- W2153101275 hasConceptScore W2153101275C126322002 @default.
- W2153101275 hasConceptScore W2153101275C143998085 @default.
- W2153101275 hasConceptScore W2153101275C2779399171 @default.
- W2153101275 hasConceptScore W2153101275C2780472235 @default.
- W2153101275 hasConceptScore W2153101275C29456083 @default.
- W2153101275 hasConceptScore W2153101275C530470458 @default.
- W2153101275 hasConceptScore W2153101275C71924100 @default.
- W2153101275 hasIssue "22" @default.
- W2153101275 hasLocation W21531012751 @default.
- W2153101275 hasLocation W21531012752 @default.
- W2153101275 hasOpenAccess W2153101275 @default.
- W2153101275 hasPrimaryLocation W21531012751 @default.
- W2153101275 hasRelatedWork W1971803455 @default.
- W2153101275 hasRelatedWork W2020264843 @default.
- W2153101275 hasRelatedWork W2041726268 @default.
- W2153101275 hasRelatedWork W2224319365 @default.
- W2153101275 hasRelatedWork W2320138859 @default.
- W2153101275 hasRelatedWork W2387047992 @default.
- W2153101275 hasRelatedWork W2902148150 @default.
- W2153101275 hasRelatedWork W3047967522 @default.
- W2153101275 hasRelatedWork W3203750400 @default.
- W2153101275 hasRelatedWork W4205830253 @default.
- W2153101275 hasVolume "1997" @default.
- W2153101275 isParatext "false" @default.
- W2153101275 isRetracted "false" @default.
- W2153101275 magId "2153101275" @default.
- W2153101275 workType "article" @default.