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- W2153103119 abstract "There have been many discussions in the literature over appropriate criteria for diagnosing oral leukoplakia, which is now defined as a white patch or plaque that cannot be characterized clinically or pathologically as any other disease. 1 WHO Collaborating Center for Oral Precancerous LesionsDefinition of leukoplakia and related lesion: An aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978; 46: 518 Abstract Full Text PDF PubMed Scopus (948) Google Scholar , 2 Axell T Pindborg JJ Smith CJ et al. An International Collaborative Group on Oral White Lesions: Oral white lesions with special reference to precancerous and tobaccorelated lesions: Conclusions of an international symposium held in Uppsala, Sweden, May 18-21, 1994. J Oral Pathol Med. 1996; 25: 49 Crossref PubMed Scopus (340) Google Scholar As a result, oral leukoplakia includes a variety of lesions that are histologically diagnosed as hyperkeratosis, parakeratosis, dysplasia, carcinoma in situ, invasive carcinoma, among others. It is essential to distinguish these nonmalignant lesions from malignant ones; however, it is difficult to make a distinction between these 2, especially in large areas of leukoplakia where histologically different entities tend to intermingle. In such cases, multiple biopsies have been conventionally taken from areas demonstrating varying appearance, followed by extirpative surgery based on histologic diagnosis. Surgeons tend to excise more tissue than necessary to make sure that malignant cells do not remain. In fact, it is almost impossible for surgeons to judge the exact size of a lesion, especially its depth, by only inspection and palpation." @default.
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- W2153103119 date "2003-03-01" @default.
- W2153103119 modified "2023-09-24" @default.
- W2153103119 title "The usefulness of intraoral ultrasonography for the treatment of large leukoplakia of the tongue" @default.
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- W2153103119 doi "https://doi.org/10.1053/joms.2003.50104" @default.
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