Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153105219> ?p ?o ?g. }
- W2153105219 endingPage "48" @default.
- W2153105219 startingPage "32" @default.
- W2153105219 abstract "T-cell receptors (TCRs) recognize peptides presented by major histocompatibility complex molecules (pMHC) to discriminate between foreign and self-antigens. Whereas T-cell recognition of foreign peptides is essential for protection against microbial pathogens, recognition of self-peptides by T cells that have escaped negative selection in the thymus can lead to autoimmune disease. Structural studies of autoimmune TCR-pMHC complexes have provided insights into the mechanisms underlying self-recognition and escape from thymic deletion. Two broad categories of self-reactive TCRs can be clearly distinguished: (i) TCRs with altered binding topologies to self-pMHC and (ii) TCRs that bind self-pMHC in the canonical diagonal orientation, but where there are structural defects or suboptimal anchors in the self-ligand. For both categories, however, the overall stability of the autoimmune TCR-pMHC complex is markedly reduced compared to anti-microbial complexes, allowing the autoreactive T cells to evade negative selection, yet retain the ability to be activated by self-antigens in target organs. Additionally, the structures provide insights into TCR cross-reactivity, which can contribute to autoimmunity by increasing the likelihood of self-pMHC recognition. Efforts are now underway to understand the impact of structural alterations in autoimmune TCR-pMHC complexes on higher order assemblies involved in TCR signaling, as well as on immunological synapse formation." @default.
- W2153105219 created "2016-06-24" @default.
- W2153105219 creator A5003193008 @default.
- W2153105219 creator A5012482272 @default.
- W2153105219 creator A5086866774 @default.
- W2153105219 date "2012-10-10" @default.
- W2153105219 modified "2023-09-25" @default.
- W2153105219 title "Structural basis for self-recognition by autoimmune T-cell receptors" @default.
- W2153105219 cites W1509401982 @default.
- W2153105219 cites W1555988808 @default.
- W2153105219 cites W1560339503 @default.
- W2153105219 cites W1574058259 @default.
- W2153105219 cites W1577612079 @default.
- W2153105219 cites W1594353637 @default.
- W2153105219 cites W1855822212 @default.
- W2153105219 cites W1966551297 @default.
- W2153105219 cites W1967983912 @default.
- W2153105219 cites W1968728160 @default.
- W2153105219 cites W1970252429 @default.
- W2153105219 cites W1971763972 @default.
- W2153105219 cites W1974374103 @default.
- W2153105219 cites W1977892868 @default.
- W2153105219 cites W1981165130 @default.
- W2153105219 cites W1983660668 @default.
- W2153105219 cites W1986216579 @default.
- W2153105219 cites W1991294321 @default.
- W2153105219 cites W1995925083 @default.
- W2153105219 cites W1996637686 @default.
- W2153105219 cites W1997598975 @default.
- W2153105219 cites W2002780937 @default.
- W2153105219 cites W2006474879 @default.
- W2153105219 cites W2007362831 @default.
- W2153105219 cites W2011352102 @default.
- W2153105219 cites W2014326164 @default.
- W2153105219 cites W2017243368 @default.
- W2153105219 cites W2017483406 @default.
- W2153105219 cites W2018027744 @default.
- W2153105219 cites W2020384794 @default.
- W2153105219 cites W2023079667 @default.
- W2153105219 cites W2026794605 @default.
- W2153105219 cites W2027277921 @default.
- W2153105219 cites W2030749217 @default.
- W2153105219 cites W2035628827 @default.
- W2153105219 cites W2038023416 @default.
- W2153105219 cites W2038509173 @default.
- W2153105219 cites W2042750081 @default.
- W2153105219 cites W2042964520 @default.
- W2153105219 cites W2044009370 @default.
- W2153105219 cites W2046202438 @default.
- W2153105219 cites W2048608556 @default.
- W2153105219 cites W2048796508 @default.
- W2153105219 cites W2049740824 @default.
- W2153105219 cites W2051539436 @default.
- W2153105219 cites W2053396500 @default.
- W2153105219 cites W2053472272 @default.
- W2153105219 cites W2059422010 @default.
- W2153105219 cites W2063057013 @default.
- W2153105219 cites W2063333925 @default.
- W2153105219 cites W2063880503 @default.
- W2153105219 cites W2066592806 @default.
- W2153105219 cites W2068750493 @default.
- W2153105219 cites W2072961622 @default.
- W2153105219 cites W2076054037 @default.
- W2153105219 cites W2077372744 @default.
- W2153105219 cites W2077864494 @default.
- W2153105219 cites W2079355826 @default.
- W2153105219 cites W2080137536 @default.
- W2153105219 cites W2080891856 @default.
- W2153105219 cites W2083095889 @default.
- W2153105219 cites W2083232111 @default.
- W2153105219 cites W2084612387 @default.
- W2153105219 cites W2085213267 @default.
- W2153105219 cites W2093503233 @default.
- W2153105219 cites W2093902610 @default.
- W2153105219 cites W2096234619 @default.
- W2153105219 cites W2096618637 @default.
- W2153105219 cites W2097419199 @default.
- W2153105219 cites W2098103958 @default.
- W2153105219 cites W2100950956 @default.
- W2153105219 cites W2101654319 @default.
- W2153105219 cites W2102153017 @default.
- W2153105219 cites W2102960796 @default.
- W2153105219 cites W2104345957 @default.
- W2153105219 cites W2106856156 @default.
- W2153105219 cites W2107644576 @default.
- W2153105219 cites W2110400139 @default.
- W2153105219 cites W2113291839 @default.
- W2153105219 cites W2114569569 @default.
- W2153105219 cites W2123679223 @default.
- W2153105219 cites W2127353647 @default.
- W2153105219 cites W2128184382 @default.
- W2153105219 cites W2129274679 @default.
- W2153105219 cites W2130138869 @default.
- W2153105219 cites W2132734959 @default.
- W2153105219 cites W2132827455 @default.
- W2153105219 cites W2134724359 @default.
- W2153105219 cites W2146074801 @default.
- W2153105219 cites W2147435185 @default.