FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153117006> ?p ?o ?g. }

• W2153117006 endingPage "719" @default.
• W2153117006 startingPage "719" @default.
• W2153117006 abstract "To date, plants have been the major source of anticancer drugs. Boldine is a natural alkaloid commonly found in the leaves and bark of Peumus boldus. In this study, we found that boldine potently inhibited the viability of the human invasive breast cancer cell lines, MDA-MB-231 (48-hour IC₅₀ 46.5±3.1 μg/mL) and MDA-MB-468 (48-hour IC₅₀ 50.8±2.7 μg/mL). Boldine had a cytotoxic effect and induced apoptosis in breast cancer cells as indicated by a higher amount of lactate dehydrogenase released, membrane permeability, and DNA fragmentation. In addition, we demonstrated that boldine induced cell cycle arrest at G2/M phase. The anticancer mechanism is associated with disruption of the mitochondrial membrane potential and release of cytochrome c in MDA-MB-231. Boldine selectively induced activation of caspase-9 and caspase-3/7, but not caspase-8. We also found that boldine could inhibit nuclear factor kappa B activation, a key molecule in tumor progression and metastasis. In addition, protein array and Western blotting analysis showed that treatment with boldine resulted in downregulation of Bcl-2 and heat shock protein 70 and upregulation of Bax in the MDA-MB-231 cell line. An acute toxicity study in rats revealed that boldine at a dose of 100 mg/kg body weight was well tolerated. Moreover, intraperitoneal injection of boldine (50 or 100 mg/kg) significantly reduced tumor size in an animal model of breast cancer. Our results suggest that boldine is a potentially useful agent for the treatment of breast cancer." @default.
• W2153117006 created "2016-06-24" @default.
• W2153117006 creator A5003234316 @default.
• W2153117006 creator A5004487403 @default.
• W2153117006 creator A5024319319 @default.
• W2153117006 creator A5027375272 @default.
• W2153117006 creator A5044842808 @default.
• W2153117006 creator A5077849801 @default.
• W2153117006 date "2014-06-01" @default.
• W2153117006 modified "2023-09-24" @default.
• W2153117006 title "Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models" @default.
• W2153117006 cites W1480948328 @default.
• W2153117006 cites W1663827195 @default.
• W2153117006 cites W1752089945 @default.
• W2153117006 cites W1965239527 @default.
• W2153117006 cites W1965734230 @default.
• W2153117006 cites W1975723879 @default.
• W2153117006 cites W1988579516 @default.
• W2153117006 cites W2004008931 @default.
• W2153117006 cites W2004632088 @default.
• W2153117006 cites W2005812025 @default.
• W2153117006 cites W2008068561 @default.
• W2153117006 cites W2010270637 @default.
• W2153117006 cites W2031803717 @default.
• W2153117006 cites W2041629470 @default.
• W2153117006 cites W2048284951 @default.
• W2153117006 cites W2060190622 @default.
• W2153117006 cites W2073746138 @default.
• W2153117006 cites W2074155500 @default.
• W2153117006 cites W2077815905 @default.
• W2153117006 cites W2083147263 @default.
• W2153117006 cites W2083375435 @default.
• W2153117006 cites W2085565086 @default.
• W2153117006 cites W2094126824 @default.
• W2153117006 cites W2109157562 @default.
• W2153117006 cites W2110211370 @default.
• W2153117006 cites W2123183032 @default.
• W2153117006 cites W2128252882 @default.
• W2153117006 cites W2133644385 @default.
• W2153117006 cites W2134634216 @default.
• W2153117006 cites W2135940820 @default.
• W2153117006 cites W2158734599 @default.
• W2153117006 cites W2234542941 @default.
• W2153117006 cites W2332770285 @default.
• W2153117006 cites W2570765298 @default.
• W2153117006 doi "https://doi.org/10.2147/dddt.s58178" @default.
• W2153117006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4057328" @default.
• W2153117006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24944509" @default.
• W2153117006 hasPublicationYear "2014" @default.
• W2153117006 type Work @default.
• W2153117006 sameAs 2153117006 @default.
• W2153117006 citedByCount "28" @default.
• W2153117006 countsByYear W21531170062014 @default.
• W2153117006 countsByYear W21531170062015 @default.
• W2153117006 countsByYear W21531170062016 @default.
• W2153117006 countsByYear W21531170062017 @default.
• W2153117006 countsByYear W21531170062019 @default.
• W2153117006 countsByYear W21531170062021 @default.
• W2153117006 countsByYear W21531170062022 @default.
• W2153117006 countsByYear W21531170062023 @default.
• W2153117006 crossrefType "journal-article" @default.
• W2153117006 hasAuthorship W2153117006A5003234316 @default.
• W2153117006 hasAuthorship W2153117006A5004487403 @default.
• W2153117006 hasAuthorship W2153117006A5024319319 @default.
• W2153117006 hasAuthorship W2153117006A5027375272 @default.
• W2153117006 hasAuthorship W2153117006A5044842808 @default.
• W2153117006 hasAuthorship W2153117006A5077849801 @default.
• W2153117006 hasBestOaLocation W21531170061 @default.
• W2153117006 hasConcept C104317684 @default.
• W2153117006 hasConcept C109316439 @default.
• W2153117006 hasConcept C121608353 @default.
• W2153117006 hasConcept C126322002 @default.
• W2153117006 hasConcept C127561419 @default.
• W2153117006 hasConcept C150903083 @default.
• W2153117006 hasConcept C154317977 @default.
• W2153117006 hasConcept C185592680 @default.
• W2153117006 hasConcept C190283241 @default.
• W2153117006 hasConcept C202751555 @default.
• W2153117006 hasConcept C207001950 @default.
• W2153117006 hasConcept C2992270614 @default.
• W2153117006 hasConcept C31573885 @default.
• W2153117006 hasConcept C41625074 @default.
• W2153117006 hasConcept C43759708 @default.
• W2153117006 hasConcept C53227056 @default.
• W2153117006 hasConcept C55493867 @default.
• W2153117006 hasConcept C71924100 @default.
• W2153117006 hasConcept C86803240 @default.
• W2153117006 hasConcept C96232424 @default.
• W2153117006 hasConcept C98274493 @default.
• W2153117006 hasConceptScore W2153117006C104317684 @default.
• W2153117006 hasConceptScore W2153117006C109316439 @default.
• W2153117006 hasConceptScore W2153117006C121608353 @default.
• W2153117006 hasConceptScore W2153117006C126322002 @default.
• W2153117006 hasConceptScore W2153117006C127561419 @default.
• W2153117006 hasConceptScore W2153117006C150903083 @default.
• W2153117006 hasConceptScore W2153117006C154317977 @default.
• W2153117006 hasConceptScore W2153117006C185592680 @default.
• W2153117006 hasConceptScore W2153117006C190283241 @default.

• next