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• W2153124549 startingPage "6213" @default.
• W2153124549 abstract "ABSTRACT Enterococci have emerged as one of the leading causes of nosocomial bloodstream, surgical site, and urinary tract infections. More recently, enterococci have been associated with biofilms, which are bacterial communities attached to a surface and encased in an extracellular polymeric matrix. The enterococcal cell surface-associated protein, Esp, enhances biofilm formation by Enterococcus faecalis in a glucose-dependent manner. Mature Esp consists of a nonrepeat N-terminal domain and a central region made up of two types of tandem repeats followed by a C-terminal membrane-spanning and anchor domain. This study was undertaken to localize the specific domain(s) of Esp that plays a role in Esp-mediated biofilm enhancement. To achieve this objective, we constructed in-frame deletion mutants expressing truncated forms of Esp in an isogenic background. By comparing strains expressing the mutant forms of Esp to those expressing wild-type Esp, we found that the strain expressing Esp lacking the N-terminal domain formed biofilms that were quantitatively less in biovolume than the strain expressing wild-type Esp. Furthermore, an E. faecalis strain expressing only the N-terminal domain of Esp fused to a heterologous protein anchor formed biofilms that were quantitatively similar to those formed by a strain expressing full-length Esp. This suggested that the minimal region contributing to Esp-mediated biofilm enhancement in E. faecalis was confined to the nonrepeat N-terminal domain. Expression of full-length E. faecalis Esp in heterologous host systems of esp -deficient Lactococcus lactis and Enterococcus faecium did not enhance biofilm formation as was observed for E. faecalis . These results suggest that Esp may require interaction with an additional E. faecalis -specific factor(s) to result in biofilm enhancement." @default.
• W2153124549 created "2016-06-24" @default.
• W2153124549 creator A5015128862 @default.
• W2153124549 creator A5029936661 @default.
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• W2153124549 date "2005-09-01" @default.
• W2153124549 modified "2023-10-17" @default.
• W2153124549 title "The N-Terminal Domain of Enterococcal Surface Protein, Esp, Is Sufficient for Esp-Mediated Biofilm Enhancement in <i>Enterococcus faecalis</i>" @default.
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• W2153124549 doi "https://doi.org/10.1128/jb.187.17.6213-6222.2005" @default.
• W2153124549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1196143" @default.
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