FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153135209> ?p ?o ?g. }

• W2153135209 endingPage "460" @default.
• W2153135209 startingPage "456" @default.
• W2153135209 abstract "Uterine contractions were induced with oxytocin in anesthetized pregnant baboons (Papio anubis) at three stages of pregnancy (days 140, 156, and 169; normal gestation length, 184 days). After the contractile activity was greater than two to three contractions every 10 minutes, R-mercapto-R, R-cyclopentamethyl enepropionic acid =[o-Trp2,Phe3,Ile4,Arg8j_oxytocin, a novel oxytocin antagonist produced in our laboratories, was given simultaneously with the oxytocin for 90 minutes. Contractile force (frequency x mean amplitude) was determined for 30 minutes before and for three 30-minute intervals after the oxytocin antagonist was administered. Animals at 140 days' gestation showed a significant (p < 0.05) decrease in contractile force in the first 30-minute interval after oxytocin antagonist infusion was initiated, whereas those at days 156 and 169 showed decreases (P < 0.05) at the second 30-minute interval. In addition, in late gestation a higher dose of oxytocin antagonist per unit of oxytocin was required to prevent uterine contractions. In conclusion, these results suggest (1) that an oxytocin antagonist can inhibit oxytocin-induced uterine contractions in the pregnant baboon and (2) that the interval from oxytocin antagonist administration to significant inhibition of uterine contractions appears to increase with advancing gestational age. Uterine contractions were induced with oxytocin in anesthetized pregnant baboons (Papio anubis) at three stages of pregnancy (days 140, 156, and 169; normal gestation length, 184 days). After the contractile activity was greater than two to three contractions every 10 minutes, R-mercapto-R, R-cyclopentamethyl enepropionic acid =[o-Trp2,Phe3,Ile4,Arg8j_oxytocin, a novel oxytocin antagonist produced in our laboratories, was given simultaneously with the oxytocin for 90 minutes. Contractile force (frequency x mean amplitude) was determined for 30 minutes before and for three 30-minute intervals after the oxytocin antagonist was administered. Animals at 140 days' gestation showed a significant (p < 0.05) decrease in contractile force in the first 30-minute interval after oxytocin antagonist infusion was initiated, whereas those at days 156 and 169 showed decreases (P < 0.05) at the second 30-minute interval. In addition, in late gestation a higher dose of oxytocin antagonist per unit of oxytocin was required to prevent uterine contractions. In conclusion, these results suggest (1) that an oxytocin antagonist can inhibit oxytocin-induced uterine contractions in the pregnant baboon and (2) that the interval from oxytocin antagonist administration to significant inhibition of uterine contractions appears to increase with advancing gestational age." @default.
• W2153135209 created "2016-06-24" @default.
• W2153135209 creator A5023957312 @default.
• W2153135209 creator A5030560997 @default.
• W2153135209 creator A5041732907 @default.
• W2153135209 date "1991-08-01" @default.
• W2153135209 modified "2023-10-11" @default.
• W2153135209 title "Inhibition of oxytocin-induced uterine contractions by an ox tocin antagonist in the pregnant baboon" @default.
• W2153135209 cites W1510777355 @default.
• W2153135209 cites W1964255419 @default.
• W2153135209 cites W1989325575 @default.
• W2153135209 cites W1990738023 @default.
• W2153135209 cites W1994624978 @default.
• W2153135209 cites W2030556522 @default.
• W2153135209 cites W2038160024 @default.
• W2153135209 cites W2070583268 @default.
• W2153135209 cites W2080437232 @default.
• W2153135209 cites W2085288958 @default.
• W2153135209 cites W2088408613 @default.
• W2153135209 cites W2161371925 @default.
• W2153135209 cites W2163622208 @default.
• W2153135209 doi "https://doi.org/10.1016/0002-9378(91)90116-9" @default.
• W2153135209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1872358" @default.
• W2153135209 hasPublicationYear "1991" @default.
• W2153135209 type Work @default.
• W2153135209 sameAs 2153135209 @default.
• W2153135209 citedByCount "20" @default.
• W2153135209 countsByYear W21531352092018 @default.
• W2153135209 crossrefType "journal-article" @default.
• W2153135209 hasAuthorship W2153135209A5023957312 @default.
• W2153135209 hasAuthorship W2153135209A5030560997 @default.
• W2153135209 hasAuthorship W2153135209A5041732907 @default.
• W2153135209 hasConcept C126322002 @default.
• W2153135209 hasConcept C134018914 @default.
• W2153135209 hasConcept C170493617 @default.
• W2153135209 hasConcept C181612422 @default.
• W2153135209 hasConcept C2776176026 @default.
• W2153135209 hasConcept C2776766599 @default.
• W2153135209 hasConcept C2776885963 @default.
• W2153135209 hasConcept C2779066055 @default.
• W2153135209 hasConcept C2779234561 @default.
• W2153135209 hasConcept C2779594886 @default.
• W2153135209 hasConcept C46973012 @default.
• W2153135209 hasConcept C54355233 @default.
• W2153135209 hasConcept C71924100 @default.
• W2153135209 hasConcept C86803240 @default.
• W2153135209 hasConceptScore W2153135209C126322002 @default.
• W2153135209 hasConceptScore W2153135209C134018914 @default.
• W2153135209 hasConceptScore W2153135209C170493617 @default.
• W2153135209 hasConceptScore W2153135209C181612422 @default.
• W2153135209 hasConceptScore W2153135209C2776176026 @default.
• W2153135209 hasConceptScore W2153135209C2776766599 @default.
• W2153135209 hasConceptScore W2153135209C2776885963 @default.
• W2153135209 hasConceptScore W2153135209C2779066055 @default.
• W2153135209 hasConceptScore W2153135209C2779234561 @default.
• W2153135209 hasConceptScore W2153135209C2779594886 @default.
• W2153135209 hasConceptScore W2153135209C46973012 @default.
• W2153135209 hasConceptScore W2153135209C54355233 @default.
• W2153135209 hasConceptScore W2153135209C71924100 @default.
• W2153135209 hasConceptScore W2153135209C86803240 @default.
• W2153135209 hasIssue "2" @default.
• W2153135209 hasLocation W21531352091 @default.
• W2153135209 hasLocation W21531352092 @default.
• W2153135209 hasOpenAccess W2153135209 @default.
• W2153135209 hasPrimaryLocation W21531352091 @default.
• W2153135209 hasRelatedWork W1608517055 @default.
• W2153135209 hasRelatedWork W2027958963 @default.
• W2153135209 hasRelatedWork W2051548602 @default.
• W2153135209 hasRelatedWork W2291241852 @default.
• W2153135209 hasRelatedWork W2774915408 @default.
• W2153135209 hasRelatedWork W4235489569 @default.
• W2153135209 hasRelatedWork W4254694048 @default.
• W2153135209 hasRelatedWork W4375859936 @default.
• W2153135209 hasRelatedWork W4380149088 @default.
• W2153135209 hasRelatedWork W2132648106 @default.
• W2153135209 hasVolume "165" @default.
• W2153135209 isParatext "false" @default.
• W2153135209 isRetracted "false" @default.
• W2153135209 magId "2153135209" @default.
• W2153135209 workType "article" @default.