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• W2153135265 startingPage "539" @default.
• W2153135265 abstract "Over 200 agents/factors have been examined in the single cell gel electrophoresis assay, more commonly known as the Comet assay, performed either in vitro or in vivo in a variety of species. Unequivocal carcinogenicity data are available for 119 of them, amongst which unequivocal Comet assay data exist for 95 agents. Of these 95 agents the prevalence of carcinogens was 88% (84/95). The carcinogens that were Comet positive (sensitivity) formed 88% (74/84), the non-carcinogens that were Comet negative (specificity) formed 64% (7/11). This simple analysis of the Comet assay has not taken account of the difference between in vitro and in vivo responses, species differences or organ and tissue differences. Also, limitations as to the conduct of the assay have not been examined in any depth. Thus, at the present time the Comet assay has high sensitivity for carcinogens, but its specificity is uncertain because few non-carcinogens have been tested." @default.
• W2153135265 created "2016-06-24" @default.
• W2153135265 creator A5001390311 @default.
• W2153135265 creator A5016835023 @default.
• W2153135265 creator A5048188548 @default.
• W2153135265 date "1998-01-01" @default.
• W2153135265 modified "2023-10-03" @default.
• W2153135265 title "Comet assay responses as indicators of carcinogen exposure" @default.
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