FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153135266> ?p ?o ?g. }

• W2153135266 endingPage "1271" @default.
• W2153135266 startingPage "1267" @default.
• W2153135266 abstract "Background Pre-eclampsia is associated with extensive endothelial-cell damage and platelet activation, resulting in lower production of vasodilator prostaglandins and increased release of the vasoconstrictors thromboxane A2 and serotonin. Damage to endothelial-cell serotonin-1 receptors leaves vasoconstriction and platelet aggregation mediated by serotonin-2 receptors unopposed. We investigated the role of ketanserin, a selective serotonin-2-receptor antagonist, in lowering the rate of pre-eclampsia among pregnant women with mild to moderate hypertension. Methods We recruited 138 pregnant women into a doubleblind, randomised, placebo-controlled trial. They had diastolic blood pressure persistently more than 80 mm Hg before 20 weeks' gestation. 69 women received ketanserin and 69 received placebo. Both groups also received aspirin. Patients were initially given two tablets daily, increased to four tablets daily in diastolic blood pressure was more than 90 mm Hg. Primary outcomes were the development of pre-eclampsia and severe hypertension, and perinatal mortality. Findings There were significantly fewer cases of preeclampsia (two vs 13; relative risk 0·15 [95% CI 0·04–0·66], p=0·006) and severe hypertension (six vs 17; p=0·02) in the ketanserin than in the placebo group. There was also a trend towards less perinatal mortality (one vs six deaths) but this was not significant (p=0·28). Rates of abruptio placentae and pre-eclampsia before 34 weeks' gestation were lower in the ketanserin group, and mean birthweight was significantly higher. Interpretation We found an association between the addition of ketanserin to aspirin and a decrease in the number of cases of pre-eclampsia and severe hypertension, as well as improved pregnancy outcome among patients with mild to moderate midtrimester hypertension." @default.
• W2153135266 created "2016-06-24" @default.
• W2153135266 creator A5050526182 @default.
• W2153135266 creator A5090857831 @default.
• W2153135266 date "1997-11-01" @default.
• W2153135266 modified "2023-09-25" @default.
• W2153135266 title "Randomised controlled trial of ketanserin and aspirin in prevention of pre-eclampsia" @default.
• W2153135266 cites W1903826534 @default.
• W2153135266 cites W1983186128 @default.
• W2153135266 cites W2015309500 @default.
• W2153135266 cites W2015794890 @default.
• W2153135266 cites W2020351746 @default.
• W2153135266 cites W2022350999 @default.
• W2153135266 cites W2043744243 @default.
• W2153135266 cites W2047959405 @default.
• W2153135266 cites W2051297423 @default.
• W2153135266 cites W2057899668 @default.
• W2153135266 cites W2066430239 @default.
• W2153135266 cites W2077320797 @default.
• W2153135266 cites W2095470682 @default.
• W2153135266 cites W2127180891 @default.
• W2153135266 cites W2130875144 @default.
• W2153135266 cites W2136997941 @default.
• W2153135266 cites W2169672940 @default.
• W2153135266 cites W2470097850 @default.
• W2153135266 doi "https://doi.org/10.1016/s0140-6736(97)06408-8" @default.
• W2153135266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9357405" @default.
• W2153135266 hasPublicationYear "1997" @default.
• W2153135266 type Work @default.
• W2153135266 sameAs 2153135266 @default.
• W2153135266 citedByCount "65" @default.
• W2153135266 countsByYear W21531352662014 @default.
• W2153135266 countsByYear W21531352662017 @default.
• W2153135266 countsByYear W21531352662018 @default.
• W2153135266 countsByYear W21531352662019 @default.
• W2153135266 countsByYear W21531352662020 @default.
• W2153135266 countsByYear W21531352662021 @default.
• W2153135266 countsByYear W21531352662022 @default.
• W2153135266 crossrefType "journal-article" @default.
• W2153135266 hasAuthorship W2153135266A5050526182 @default.
• W2153135266 hasAuthorship W2153135266A5090857831 @default.
• W2153135266 hasConcept C126322002 @default.
• W2153135266 hasConcept C131872663 @default.
• W2153135266 hasConcept C134018914 @default.
• W2153135266 hasConcept C142724271 @default.
• W2153135266 hasConcept C170493617 @default.
• W2153135266 hasConcept C204787440 @default.
• W2153135266 hasConcept C27081682 @default.
• W2153135266 hasConcept C2775864247 @default.
• W2153135266 hasConcept C2777218350 @default.
• W2153135266 hasConcept C2777628954 @default.
• W2153135266 hasConcept C2777785214 @default.
• W2153135266 hasConcept C2779234561 @default.
• W2153135266 hasConcept C2781276381 @default.
• W2153135266 hasConcept C42219234 @default.
• W2153135266 hasConcept C53910766 @default.
• W2153135266 hasConcept C54355233 @default.
• W2153135266 hasConcept C71924100 @default.
• W2153135266 hasConcept C84393581 @default.
• W2153135266 hasConcept C86803240 @default.
• W2153135266 hasConceptScore W2153135266C126322002 @default.
• W2153135266 hasConceptScore W2153135266C131872663 @default.
• W2153135266 hasConceptScore W2153135266C134018914 @default.
• W2153135266 hasConceptScore W2153135266C142724271 @default.
• W2153135266 hasConceptScore W2153135266C170493617 @default.
• W2153135266 hasConceptScore W2153135266C204787440 @default.
• W2153135266 hasConceptScore W2153135266C27081682 @default.
• W2153135266 hasConceptScore W2153135266C2775864247 @default.
• W2153135266 hasConceptScore W2153135266C2777218350 @default.
• W2153135266 hasConceptScore W2153135266C2777628954 @default.
• W2153135266 hasConceptScore W2153135266C2777785214 @default.
• W2153135266 hasConceptScore W2153135266C2779234561 @default.
• W2153135266 hasConceptScore W2153135266C2781276381 @default.
• W2153135266 hasConceptScore W2153135266C42219234 @default.
• W2153135266 hasConceptScore W2153135266C53910766 @default.
• W2153135266 hasConceptScore W2153135266C54355233 @default.
• W2153135266 hasConceptScore W2153135266C71924100 @default.
• W2153135266 hasConceptScore W2153135266C84393581 @default.
• W2153135266 hasConceptScore W2153135266C86803240 @default.
• W2153135266 hasIssue "9087" @default.
• W2153135266 hasLocation W21531352661 @default.
• W2153135266 hasLocation W21531352662 @default.
• W2153135266 hasOpenAccess W2153135266 @default.
• W2153135266 hasPrimaryLocation W21531352661 @default.
• W2153135266 hasRelatedWork W1522849455 @default.
• W2153135266 hasRelatedWork W1971453675 @default.
• W2153135266 hasRelatedWork W2004959129 @default.
• W2153135266 hasRelatedWork W2027622212 @default.
• W2153135266 hasRelatedWork W2048991606 @default.
• W2153135266 hasRelatedWork W2055572014 @default.
• W2153135266 hasRelatedWork W2107899720 @default.
• W2153135266 hasRelatedWork W2128286595 @default.
• W2153135266 hasRelatedWork W3028799611 @default.
• W2153135266 hasRelatedWork W4241062279 @default.
• W2153135266 hasVolume "350" @default.
• W2153135266 isParatext "false" @default.
• W2153135266 isRetracted "false" @default.
• W2153135266 magId "2153135266" @default.

• next