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- W2153149713 abstract "During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection." @default.
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- W2153149713 date "2003-12-01" @default.
- W2153149713 modified "2023-10-15" @default.
- W2153149713 title "Senseless acts as a binary switch during sensory organ precursor selection" @default.
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- W2153149713 doi "https://doi.org/10.1101/gad.1122403" @default.
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