FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153157062> ?p ?o ?g. }

• W2153157062 endingPage "e85388" @default.
• W2153157062 startingPage "e85388" @default.
• W2153157062 abstract "Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs. In human oncology, the importance of the EGFR/HER-2/KRAS signalling pathway in gastric cancer is well established, and HER-2 testing is required before initiating therapy. Conversely, this pathway has never been investigated in canine gastric tumours. A total of 19 canine gastric epithelial neoplasms (5 adenomas and 14 carcinomas) were retrospectively evaluated for EGFR/HER-2 immunohistochemical expression and KRAS mutational status. Five (35.7%) carcinomas were classified as intestinal-type and 9 (64.3%) as diffuse-type. EGFR was overexpressed (≥1+) in 8 (42.1%) cases and HER-2 (3+) in 11 (57.9%) cases, regardless of tumour location or biological behaviour. The percentage of EGFR-positive tumours was significantly higher in the intestinal-type (80%) than in the diffuse-type (11.1%, p = 0.023). KRAS gene was wild type in 18 cases, whereas one mucinous carcinoma harboured a point mutation at codon 12 (G12R). EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms. The potential presence of KRAS mutation should be taken into account as a possible mechanism of drug resistance. Further studies are necessary to evaluate the role of dog as a model for human gastric cancer." @default.
• W2153157062 created "2016-06-24" @default.
• W2153157062 creator A5001489063 @default.
• W2153157062 creator A5002378349 @default.
• W2153157062 creator A5006929101 @default.
• W2153157062 creator A5018379221 @default.
• W2153157062 creator A5022868539 @default.
• W2153157062 creator A5045890136 @default.
• W2153157062 creator A5058164461 @default.
• W2153157062 creator A5065419411 @default.
• W2153157062 creator A5074441183 @default.
• W2153157062 creator A5075055655 @default.
• W2153157062 creator A5087989451 @default.
• W2153157062 date "2014-01-15" @default.
• W2153157062 modified "2023-09-28" @default.
• W2153157062 title "EGFR, HER-2 and KRAS in Canine Gastric Epithelial Tumors: A Potential Human Model?" @default.
• W2153157062 cites W1496253965 @default.
• W2153157062 cites W1945181719 @default.
• W2153157062 cites W1971681203 @default.
• W2153157062 cites W1984460306 @default.
• W2153157062 cites W1986897680 @default.
• W2153157062 cites W1987009448 @default.
• W2153157062 cites W1988429791 @default.
• W2153157062 cites W1988472300 @default.
• W2153157062 cites W1994461391 @default.
• W2153157062 cites W2001302850 @default.
• W2153157062 cites W2002001086 @default.
• W2153157062 cites W2002259478 @default.
• W2153157062 cites W2003336662 @default.
• W2153157062 cites W2015956013 @default.
• W2153157062 cites W2027820203 @default.
• W2153157062 cites W2031415590 @default.
• W2153157062 cites W2038036243 @default.
• W2153157062 cites W2040083298 @default.
• W2153157062 cites W2044584393 @default.
• W2153157062 cites W2045155957 @default.
• W2153157062 cites W205782301 @default.
• W2153157062 cites W2072031500 @default.
• W2153157062 cites W2075653061 @default.
• W2153157062 cites W2075967637 @default.
• W2153157062 cites W2083695927 @default.
• W2153157062 cites W2093953414 @default.
• W2153157062 cites W2096287391 @default.
• W2153157062 cites W2100439220 @default.
• W2153157062 cites W2119733072 @default.
• W2153157062 cites W2142564546 @default.
• W2153157062 cites W2142850084 @default.
• W2153157062 cites W2161516303 @default.
• W2153157062 cites W2166659604 @default.
• W2153157062 cites W2169560977 @default.
• W2153157062 cites W2338576041 @default.
• W2153157062 cites W4244954924 @default.
• W2153157062 cites W758358663 @default.
• W2153157062 doi "https://doi.org/10.1371/journal.pone.0085388" @default.
• W2153157062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893207" @default.
• W2153157062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24454858" @default.
• W2153157062 hasPublicationYear "2014" @default.
• W2153157062 type Work @default.
• W2153157062 sameAs 2153157062 @default.
• W2153157062 citedByCount "33" @default.
• W2153157062 countsByYear W21531570622013 @default.
• W2153157062 countsByYear W21531570622014 @default.
• W2153157062 countsByYear W21531570622015 @default.
• W2153157062 countsByYear W21531570622016 @default.
• W2153157062 countsByYear W21531570622017 @default.
• W2153157062 countsByYear W21531570622018 @default.
• W2153157062 countsByYear W21531570622019 @default.
• W2153157062 countsByYear W21531570622020 @default.
• W2153157062 countsByYear W21531570622021 @default.
• W2153157062 countsByYear W21531570622022 @default.
• W2153157062 crossrefType "journal-article" @default.
• W2153157062 hasAuthorship W2153157062A5001489063 @default.
• W2153157062 hasAuthorship W2153157062A5002378349 @default.
• W2153157062 hasAuthorship W2153157062A5006929101 @default.
• W2153157062 hasAuthorship W2153157062A5018379221 @default.
• W2153157062 hasAuthorship W2153157062A5022868539 @default.
• W2153157062 hasAuthorship W2153157062A5045890136 @default.
• W2153157062 hasAuthorship W2153157062A5058164461 @default.
• W2153157062 hasAuthorship W2153157062A5065419411 @default.
• W2153157062 hasAuthorship W2153157062A5074441183 @default.
• W2153157062 hasAuthorship W2153157062A5075055655 @default.
• W2153157062 hasAuthorship W2153157062A5087989451 @default.
• W2153157062 hasBestOaLocation W21531570621 @default.
• W2153157062 hasConcept C121608353 @default.
• W2153157062 hasConcept C126322002 @default.
• W2153157062 hasConcept C142724271 @default.
• W2153157062 hasConcept C204232928 @default.
• W2153157062 hasConcept C2779438470 @default.
• W2153157062 hasConcept C2781187634 @default.
• W2153157062 hasConcept C2781230642 @default.
• W2153157062 hasConcept C502942594 @default.
• W2153157062 hasConcept C526805850 @default.
• W2153157062 hasConcept C71924100 @default.
• W2153157062 hasConcept C86803240 @default.
• W2153157062 hasConceptScore W2153157062C121608353 @default.
• W2153157062 hasConceptScore W2153157062C126322002 @default.
• W2153157062 hasConceptScore W2153157062C142724271 @default.
• W2153157062 hasConceptScore W2153157062C204232928 @default.

• next