FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153161303> ?p ?o ?g. }

• W2153161303 endingPage "85" @default.
• W2153161303 startingPage "72" @default.
• W2153161303 abstract "We elaborate herein a novel theory of basal ganglia function that accounts for why palatable, energy-dense foods retain high incentive value even when immediate physiological energy requirements have been met. Basal ganglia function has been studied from the perspective of topographical segregation of processing within parallel circuits, with primary focus on motor control and cognition. Recent findings suggest, however, that the striatum can act as an integrated unit to modulate motivational state. We describe evidence that the striatal enkephalin system, which regulates the hedonic impact of preferred foods, undergoes coordinated gene expression changes that track current motivational state with regard to food intake. Striatal enkephalin gene expression is also downregulated by an intrastriatal infusion of a cholinergic muscarinic antagonist, a manipulation that greatly suppresses food intake. To account for these findings, we propose that signaling through a hypothalamic-midline thalamic-striatal axis impinges on the cholinergic interneurons of the striatum, which via their large, overlapping axonal fields act as a network to modulate enkephalin-containing striatal output neurons. A key relay in this circuit is the paraventricular thalamic nucleus, which receives convergent input from orexin-coded hypothalamic energy-sensing and behavioral state-regulating neurons, as well as from circadian oscillators, and projects to cholinergic interneurons throughout the striatal complex. We hypothesize that this system evolved to coordinate feeding and arousal, and to prolong the feeding central motivational state beyond the fulfillment of acute energy needs, thereby promoting overeating and the consequent development of an energy reserve for potential future food shortages." @default.
• W2153161303 created "2016-06-24" @default.
• W2153161303 creator A5006794016 @default.
• W2153161303 creator A5018633729 @default.
• W2153161303 creator A5088180562 @default.
• W2153161303 date "2005-10-27" @default.
• W2153161303 modified "2023-10-10" @default.
• W2153161303 title "A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward" @default.
• W2153161303 cites W1488496267 @default.
• W2153161303 cites W1510812756 @default.
• W2153161303 cites W1511397211 @default.
• W2153161303 cites W1578111329 @default.
• W2153161303 cites W1583790097 @default.
• W2153161303 cites W1627229807 @default.
• W2153161303 cites W1671833268 @default.
• W2153161303 cites W1766594753 @default.
• W2153161303 cites W1776364276 @default.
• W2153161303 cites W1902877024 @default.
• W2153161303 cites W1938381539 @default.
• W2153161303 cites W1963623154 @default.
• W2153161303 cites W1964384291 @default.
• W2153161303 cites W1966980993 @default.
• W2153161303 cites W1970817877 @default.
• W2153161303 cites W1975232919 @default.
• W2153161303 cites W1977760337 @default.
• W2153161303 cites W1979039459 @default.
• W2153161303 cites W1980856647 @default.
• W2153161303 cites W1982742436 @default.
• W2153161303 cites W1985938249 @default.
• W2153161303 cites W1988975012 @default.
• W2153161303 cites W1989416066 @default.
• W2153161303 cites W1990235505 @default.
• W2153161303 cites W1991108340 @default.
• W2153161303 cites W1993116569 @default.
• W2153161303 cites W1994483275 @default.
• W2153161303 cites W1998722012 @default.
• W2153161303 cites W2000274215 @default.
• W2153161303 cites W2000556605 @default.
• W2153161303 cites W2000703669 @default.
• W2153161303 cites W2000938346 @default.
• W2153161303 cites W2005262731 @default.
• W2153161303 cites W2005890883 @default.
• W2153161303 cites W2007387523 @default.
• W2153161303 cites W2014076809 @default.
• W2153161303 cites W2014415095 @default.
• W2153161303 cites W2016114488 @default.
• W2153161303 cites W2017200167 @default.
• W2153161303 cites W2017386708 @default.
• W2153161303 cites W2017934537 @default.
• W2153161303 cites W2018527534 @default.
• W2153161303 cites W2019619528 @default.
• W2153161303 cites W2022062211 @default.
• W2153161303 cites W2022174561 @default.
• W2153161303 cites W2025936719 @default.
• W2153161303 cites W2026212466 @default.
• W2153161303 cites W2026358981 @default.
• W2153161303 cites W2027180375 @default.
• W2153161303 cites W2031901461 @default.
• W2153161303 cites W2032284808 @default.
• W2153161303 cites W2032471499 @default.
• W2153161303 cites W2035027836 @default.
• W2153161303 cites W2035283068 @default.
• W2153161303 cites W2037457092 @default.
• W2153161303 cites W2039697322 @default.
• W2153161303 cites W2040689703 @default.
• W2153161303 cites W2043956531 @default.
• W2153161303 cites W2045065112 @default.
• W2153161303 cites W2045948521 @default.
• W2153161303 cites W2049547155 @default.
• W2153161303 cites W2050760271 @default.
• W2153161303 cites W2051508663 @default.
• W2153161303 cites W2053400076 @default.
• W2153161303 cites W2054170086 @default.
• W2153161303 cites W2058315281 @default.
• W2153161303 cites W2062084429 @default.
• W2153161303 cites W2062817206 @default.
• W2153161303 cites W2063167199 @default.
• W2153161303 cites W2064500901 @default.
• W2153161303 cites W2065902274 @default.
• W2153161303 cites W2069310569 @default.
• W2153161303 cites W2071187901 @default.
• W2153161303 cites W2072308972 @default.
• W2153161303 cites W2073595900 @default.
• W2153161303 cites W2074104060 @default.
• W2153161303 cites W2075210699 @default.
• W2153161303 cites W2076140644 @default.
• W2153161303 cites W2079311820 @default.
• W2153161303 cites W2079756607 @default.
• W2153161303 cites W2080664107 @default.
• W2153161303 cites W2083259973 @default.
• W2153161303 cites W2085116272 @default.
• W2153161303 cites W2086249342 @default.
• W2153161303 cites W2088443095 @default.
• W2153161303 cites W2089473311 @default.
• W2153161303 cites W2093349190 @default.
• W2153161303 cites W2093948960 @default.
• W2153161303 cites W2094296755 @default.
• W2153161303 cites W2096178360 @default.

• next